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FIGURE 5 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

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Finlay, JB; Abi Hachem, R; Jang, DW; Osazuwa-Peters, N; Goldstein, BJ
June 6, 2023

<p>Glandular and olfactory ensheathing cell markers are present in low-grade ONB and are associated with increased survival. <b>A,</b> UMAP visualization of non-tumor olfactory mucosa scRNA-seq data depicts the cell type–specific expression of selected transcripts. PLP1 and S100B are expressed in olfactory ensheathing cells (OEC, red arrow); SOX9 is highly expressed in Bowman's glands (black arrow) and the TRPM5<sup>+</sup> subset of microvillar cells (blue arrow). Scale bar shows normalized counts. <b>B,</b> Kaplan–Meier survival curves showing significant survival advantage in ONB tumors with higher expression of Bowman's gland and OEC markers. Statistical significance determined by log-rank test. <b>C,</b> SOX9<sup>+</sup> cells are rarely Ki-67<sup>+</sup> and do not colocalize with SOX2. In contrast, some SOX2<sup>+</sup> cells show evidence of proliferation based on Ki-67 staining (arrowheads). <b>D,</b> The presence of S100B<sup>+</sup> cells in a grade I ONB. Ki-67 costaining confirms the presence of the occasional proliferative S100B<sup>+</sup> cell (arrowhead). In A, resp = respiratory; RBC = red blood cell; sus = sustentacular; in C and D, scale bar = 50 μm.</p>

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Publication Date

June 6, 2023
 

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Finlay, J. B., Abi Hachem, R., Jang, D. W., Osazuwa-Peters, N., & Goldstein, B. J. (2023). FIGURE 5 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma. https://doi.org/10.1158/2767-9764.23302004.v1
Finlay, John B., Ralph Abi Hachem, David W. Jang, Nosayaba Osazuwa-Peters, and Bradley J. Goldstein. “FIGURE 5 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma,” June 6, 2023. https://doi.org/10.1158/2767-9764.23302004.v1.
Finlay JB, Abi Hachem R, Jang DW, Osazuwa-Peters N, Goldstein BJ. FIGURE 5 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma. 2023.
Finlay, John B., et al. FIGURE 5 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma. 6 June 2023. Crossref, doi:10.1158/2767-9764.23302004.v1.
Finlay JB, Abi Hachem R, Jang DW, Osazuwa-Peters N, Goldstein BJ. FIGURE 5 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma. 2023.

DOI

Publication Date

June 6, 2023