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Effects of food-based interventions in the management of chemoradiotherapy-induced nausea and vomiting: a systematic review.

Publication ,  Journal Article
Molassiotis, A; Zhao, IY; Crichton, M; Olver, I; Fleury, M; Giusti, R; Scotte, F; Affronti, ML
Published in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
June 2023

Cancer treatment-related nausea and vomiting continue to be common and distressing symptoms for patients, despite improvements in antiemetics. Dietary modifications could potentially improve this symptom experience. Clinicians frequently provide dietary advice to patients, although the evidence base of such suggestions or recommendations is not clear.This systematic review aimed to examine the current literature on food interventions associated with improvements in cancer treatment-related nausea and vomiting.Eight electronic databases were searched with a specific search term strategy covering trials without time or language limitations. Eligible studies focused on a food substance, defined as any nutritious substance that people eat or drink to maintain life and well-being. Trials in children and adults during chemotherapy or radiotherapy were included. Cochrane risk of bias tool was used to assess trial quality and GRADE was used to assess the certainty in the effect of each outcome.Seventeen trials were included, 3 focusing on children and 14 on adults. Two trials included patients receiving radiation. Ten out of 17 trials (59%) had a high risk of bias. Strongest evidence with highest certainty was found for dietary counseling to meet macronutrient requirements in reducing incidence of radiotherapy-related nausea and vomiting in adults (n=2 studies; n=124 participants; GRADE level: moderate). There was also moderate certainty in the beneficial effect of protein supplementation on nausea and vomiting incidence in adults during radiotherapy (n=2 studies; n=124 participants; GRADE level: moderate). A significant positive effect on CINV incidence and/or severity in adults was also found for dietary counseling to meet macronutrient requirements during chemotherapy, a peppermint drink, scaly wood mushroom, chamomile, protein with ginger, and a colorless odorless diet (GRADE level: low to very low).The review identified food-based approaches that could improve the nausea and vomiting experience in patients with cancer and provide guidance to clinicians. However, confidence in these findings was low and studies were heterogeneous and mostly of low quality, requiring further investigation before stronger recommendations can be made. Future research is needed to confirm efficacy and safety.PROSPERO CRD42022341154.

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Published In

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

DOI

EISSN

1433-7339

ISSN

0941-4355

Publication Date

June 2023

Volume

31

Issue

7

Start / End Page

413

Related Subject Headings

  • Vomiting
  • Oncology & Carcinogenesis
  • Neoplasms
  • Nausea
  • Humans
  • Child
  • Chemoradiotherapy
  • Antiemetics
  • Adult
  • 52 Psychology
 

Citation

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MLA
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Molassiotis, A., Zhao, I. Y., Crichton, M., Olver, I., Fleury, M., Giusti, R., … Affronti, M. L. (2023). Effects of food-based interventions in the management of chemoradiotherapy-induced nausea and vomiting: a systematic review. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer, 31(7), 413. https://doi.org/10.1007/s00520-023-07879-0
Molassiotis, A., I. Y. Zhao, M. Crichton, I. Olver, M. Fleury, R. Giusti, F. Scotte, and M. L. Affronti. “Effects of food-based interventions in the management of chemoradiotherapy-induced nausea and vomiting: a systematic review.Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer 31, no. 7 (June 2023): 413. https://doi.org/10.1007/s00520-023-07879-0.
Molassiotis A, Zhao IY, Crichton M, Olver I, Fleury M, Giusti R, et al. Effects of food-based interventions in the management of chemoradiotherapy-induced nausea and vomiting: a systematic review. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2023 Jun;31(7):413.
Molassiotis, A., et al. “Effects of food-based interventions in the management of chemoradiotherapy-induced nausea and vomiting: a systematic review.Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer, vol. 31, no. 7, June 2023, p. 413. Epmc, doi:10.1007/s00520-023-07879-0.
Molassiotis A, Zhao IY, Crichton M, Olver I, Fleury M, Giusti R, Scotte F, Affronti ML. Effects of food-based interventions in the management of chemoradiotherapy-induced nausea and vomiting: a systematic review. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2023 Jun;31(7):413.
Journal cover image

Published In

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

DOI

EISSN

1433-7339

ISSN

0941-4355

Publication Date

June 2023

Volume

31

Issue

7

Start / End Page

413

Related Subject Headings

  • Vomiting
  • Oncology & Carcinogenesis
  • Neoplasms
  • Nausea
  • Humans
  • Child
  • Chemoradiotherapy
  • Antiemetics
  • Adult
  • 52 Psychology