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Associations between urbanicity and spinal cord astrocytoma management and outcomes.

Publication ,  Journal Article
Sykes, DAW; Waguia, R; Abu-Bonsrah, N; Price, M; Dalton, T; Sperber, J; Owolo, E; Hockenberry, H; Bishop, B; Kruchko, C; Barnholtz-Sloan, JS ...
Published in: Cancer Epidemiol
October 2023

BACKGROUND: The management of spinal cord astrocytomas (SCAs) remains controversial and may include any combination of surgery, radiation, and chemotherapy. Factors such as urbanicity (metropolitan versus non-metropolitan residence) are shown to be associated with patterns of treatment and clinical outcomes in a variety of cancers, but the role urbanicity plays in SCA treatment remains unknown. METHODS: The Central Brain Tumor Registry of the United States (CBTRUS) analytic dataset, which combines data from CDC's National Program of Cancer Registries (NPCR) and NCI's Surveillance, Epidemiology, and End Results Programs, was used to identify individuals with SCAs between 2004 and 2019. Individuals' county of residence was classified as metropolitan or non-metropolitan. Multivariable logistic regression models were used to evaluate associations between urbanicity and SCA. Cox proportional hazard models were constructed to assess the effect of urbanicity on survival using the NPCR survival dataset (2004-2018). RESULTS: 1697 metropolitan and 268 non-metropolitan SCA cases were identified. The cohorts did not differ in age or gender composition. The populations had different racial/ethnic compositions, with a higher White non-Hispanic population in the non-metropolitan cohort (86 % vs 66 %, p < 0.001) and a greater Black non-Hispanic population in the metropolitan cohort (14 % vs 9.9 %, p < 0.001). There were no significant differences in likelihood of receiving comprehensive treatment (OR=0.99, 95 % CI [0.56, 1.65], p = >0.9), or survival (hazard ratio [HR]=0.92, p = 0.4) when non-metropolitan and metropolitan cases were compared. In the metropolitan cohort, there were statistically significant differences in SCA treatment patterns when stratified by race/ethnicity (p = 0.002). CONCLUSIONS: Urbanicity does not significantly impact SCA management or survival. Race/ethnicity may be associated with likelihood of receiving certain SCA treatments in metropolitan communities.

Duke Scholars

Published In

Cancer Epidemiol

DOI

EISSN

1877-783X

Publication Date

October 2023

Volume

86

Start / End Page

102431

Location

Netherlands

Related Subject Headings

  • Oncology & Carcinogenesis
  • 4202 Epidemiology
  • 3211 Oncology and carcinogenesis
  • 1117 Public Health and Health Services
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sykes, D. A. W., Waguia, R., Abu-Bonsrah, N., Price, M., Dalton, T., Sperber, J., … Goodwin, C. R. (2023). Associations between urbanicity and spinal cord astrocytoma management and outcomes. Cancer Epidemiol, 86, 102431. https://doi.org/10.1016/j.canep.2023.102431
Sykes, David A. W., Romaric Waguia, Nancy Abu-Bonsrah, Mackenzie Price, Tara Dalton, Jacob Sperber, Edwin Owolo, et al. “Associations between urbanicity and spinal cord astrocytoma management and outcomes.Cancer Epidemiol 86 (October 2023): 102431. https://doi.org/10.1016/j.canep.2023.102431.
Sykes DAW, Waguia R, Abu-Bonsrah N, Price M, Dalton T, Sperber J, et al. Associations between urbanicity and spinal cord astrocytoma management and outcomes. Cancer Epidemiol. 2023 Oct;86:102431.
Sykes, David A. W., et al. “Associations between urbanicity and spinal cord astrocytoma management and outcomes.Cancer Epidemiol, vol. 86, Oct. 2023, p. 102431. Pubmed, doi:10.1016/j.canep.2023.102431.
Sykes DAW, Waguia R, Abu-Bonsrah N, Price M, Dalton T, Sperber J, Owolo E, Hockenberry H, Bishop B, Kruchko C, Barnholtz-Sloan JS, Erickson M, Ostrom QT, Goodwin CR. Associations between urbanicity and spinal cord astrocytoma management and outcomes. Cancer Epidemiol. 2023 Oct;86:102431.
Journal cover image

Published In

Cancer Epidemiol

DOI

EISSN

1877-783X

Publication Date

October 2023

Volume

86

Start / End Page

102431

Location

Netherlands

Related Subject Headings

  • Oncology & Carcinogenesis
  • 4202 Epidemiology
  • 3211 Oncology and carcinogenesis
  • 1117 Public Health and Health Services
  • 1112 Oncology and Carcinogenesis