Synthesis and biological evaluation of 5,7-dihydroxyflavanone derivatives as antimicrobial agents.
Publication
, Journal Article
Zhang, X; Khalidi, O; Kim, SY; Wang, R; Schultz, V; Cress, BF; Gross, RA; Koffas, MAG; Linhardt, RJ
Published in: Bioorg Med Chem Lett
July 1, 2016
A series of 5,7-dihydroxyflavanone derivatives were efficiently synthesized. Their antimicrobial efficacy on Gram-negative, Gram-positive bacteria and yeast were evaluated. Among these compounds, most of the halogenated derivatives exhibited the best antimicrobial activity against Gram-positive bacteria, the yeast Saccharomyces cerevisiae, and the Gram-negative bacterium Vibrio cholerae. The cytotoxicities of these compounds were low as evaluated on HepG2 cells using a cell viability assay. This study suggests that halogenated flavanones might represent promising pharmacological candidates for further drug development.
Duke Scholars
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Published In
Bioorg Med Chem Lett
DOI
EISSN
1464-3405
Publication Date
July 1, 2016
Volume
26
Issue
13
Start / End Page
3089 / 3092
Location
England
Related Subject Headings
- Structure-Activity Relationship
- Saccharomyces cerevisiae
- Molecular Structure
- Microbial Sensitivity Tests
- Medicinal & Biomolecular Chemistry
- Humans
- Hep G2 Cells
- Gram-Positive Bacteria
- Gram-Negative Bacteria
- Flavanones
Citation
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Chicago
ICMJE
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Zhang, X., Khalidi, O., Kim, S. Y., Wang, R., Schultz, V., Cress, B. F., … Linhardt, R. J. (2016). Synthesis and biological evaluation of 5,7-dihydroxyflavanone derivatives as antimicrobial agents. Bioorg Med Chem Lett, 26(13), 3089–3092. https://doi.org/10.1016/j.bmcl.2016.05.003
Zhang, Xing, Omar Khalidi, So Young Kim, Ruitong Wang, Victor Schultz, Brady F. Cress, Richard A. Gross, Mattheos A. G. Koffas, and Robert J. Linhardt. “Synthesis and biological evaluation of 5,7-dihydroxyflavanone derivatives as antimicrobial agents.” Bioorg Med Chem Lett 26, no. 13 (July 1, 2016): 3089–92. https://doi.org/10.1016/j.bmcl.2016.05.003.
Zhang X, Khalidi O, Kim SY, Wang R, Schultz V, Cress BF, et al. Synthesis and biological evaluation of 5,7-dihydroxyflavanone derivatives as antimicrobial agents. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3089–92.
Zhang, Xing, et al. “Synthesis and biological evaluation of 5,7-dihydroxyflavanone derivatives as antimicrobial agents.” Bioorg Med Chem Lett, vol. 26, no. 13, July 2016, pp. 3089–92. Pubmed, doi:10.1016/j.bmcl.2016.05.003.
Zhang X, Khalidi O, Kim SY, Wang R, Schultz V, Cress BF, Gross RA, Koffas MAG, Linhardt RJ. Synthesis and biological evaluation of 5,7-dihydroxyflavanone derivatives as antimicrobial agents. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3089–3092.
Published In
Bioorg Med Chem Lett
DOI
EISSN
1464-3405
Publication Date
July 1, 2016
Volume
26
Issue
13
Start / End Page
3089 / 3092
Location
England
Related Subject Headings
- Structure-Activity Relationship
- Saccharomyces cerevisiae
- Molecular Structure
- Microbial Sensitivity Tests
- Medicinal & Biomolecular Chemistry
- Humans
- Hep G2 Cells
- Gram-Positive Bacteria
- Gram-Negative Bacteria
- Flavanones