Mutations on fibrinogen (gamma 316-322) are associated with reduction in platelet adhesion under flow conditions.
Publication
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Remijn, JA; Lounes, KC; Hogan, KA; Lord, ST; Galanakis, DK; Sixma, JJ; De Groot, PG
Published in: Annals of the New York Academy of Sciences
January 2001
In this paper we report on studies of platelet adhesion to several fibrinogen gamma chain variants under physiological flow conditions. Reduced platelet adhesion was found to patient dysfibrinogen Vlissingen and its recombinant form (deletion of gamma 319-320). Furthermore, substitutions of the amino acids 318, 320, or both in the recombinant fibrinogen gamma chain showed a strong decrease in platelet adhesion under flow conditions in our perfusion system. Antibodies raised against peptides covering these sequences inhibited platelet adhesion completely, which suggested that the gamma 316-322 sequence could be involved in platelet adhesion in flowing blood.
Duke Scholars
Published In
Annals of the New York Academy of Sciences
DOI
EISSN
1749-6632
ISSN
0077-8923
Publication Date
January 2001
Volume
936
Start / End Page
444 / 448
Related Subject Headings
- Peptides
- Mutation
- Humans
- General Science & Technology
- Fibrinogen
- Cell Adhesion
- Blood Platelets
- Antibodies
Citation
APA
Chicago
ICMJE
MLA
NLM
Remijn, J. A., Lounes, K. C., Hogan, K. A., Lord, S. T., Galanakis, D. K., Sixma, J. J., & De Groot, P. G. (2001). Mutations on fibrinogen (gamma 316-322) are associated with reduction in platelet adhesion under flow conditions. In Annals of the New York Academy of Sciences (Vol. 936, pp. 444–448). https://doi.org/10.1111/j.1749-6632.2001.tb03528.x
Remijn, J. A., K. C. Lounes, K. A. Hogan, S. T. Lord, D. K. Galanakis, J. J. Sixma, and P. G. De Groot. “Mutations on fibrinogen (gamma 316-322) are associated with reduction in platelet adhesion under flow conditions.” In Annals of the New York Academy of Sciences, 936:444–48, 2001. https://doi.org/10.1111/j.1749-6632.2001.tb03528.x.
Remijn JA, Lounes KC, Hogan KA, Lord ST, Galanakis DK, Sixma JJ, et al. Mutations on fibrinogen (gamma 316-322) are associated with reduction in platelet adhesion under flow conditions. In: Annals of the New York Academy of Sciences. 2001. p. 444–8.
Remijn, J. A., et al. “Mutations on fibrinogen (gamma 316-322) are associated with reduction in platelet adhesion under flow conditions.” Annals of the New York Academy of Sciences, vol. 936, 2001, pp. 444–48. Epmc, doi:10.1111/j.1749-6632.2001.tb03528.x.
Remijn JA, Lounes KC, Hogan KA, Lord ST, Galanakis DK, Sixma JJ, De Groot PG. Mutations on fibrinogen (gamma 316-322) are associated with reduction in platelet adhesion under flow conditions. Annals of the New York Academy of Sciences. 2001. p. 444–448.
Published In
Annals of the New York Academy of Sciences
DOI
EISSN
1749-6632
ISSN
0077-8923
Publication Date
January 2001
Volume
936
Start / End Page
444 / 448
Related Subject Headings
- Peptides
- Mutation
- Humans
- General Science & Technology
- Fibrinogen
- Cell Adhesion
- Blood Platelets
- Antibodies