The formation of beta fibrin requires a functional a site.
Publication
, Conference
Hogan, KA; Bolliger, B; Okumura, N; Lord, ST
Published in: Annals of the New York Academy of Sciences
January 2001
We used recombinant fibrinogens in which the a site is disrupted to examine beta-fibrin formation in the absence of a functional a site. Our variants have only b sites available, and they showed no evidence of fibrin polymer formation after cleavage of FpB with venzyme. We conclude that B-b interactions are not strong enough to induce clot formation. Our studies do not rule out the involvement of b in the formation of beta-fibrin, yet they do provide evidence that a is likely to be essential in the formation of beta-fibrin.
Duke Scholars
Published In
Annals of the New York Academy of Sciences
DOI
EISSN
1749-6632
ISSN
0077-8923
Publication Date
January 2001
Volume
936
Start / End Page
219 / 222
Related Subject Headings
- Recombinant Proteins
- General Science & Technology
- Fibrinogen
- Fibrin
Citation
APA
Chicago
ICMJE
MLA
NLM
Hogan, K. A., Bolliger, B., Okumura, N., & Lord, S. T. (2001). The formation of beta fibrin requires a functional a site. In Annals of the New York Academy of Sciences (Vol. 936, pp. 219–222). https://doi.org/10.1111/j.1749-6632.2001.tb03509.x
Hogan, K. A., B. Bolliger, N. Okumura, and S. T. Lord. “The formation of beta fibrin requires a functional a site.” In Annals of the New York Academy of Sciences, 936:219–22, 2001. https://doi.org/10.1111/j.1749-6632.2001.tb03509.x.
Hogan KA, Bolliger B, Okumura N, Lord ST. The formation of beta fibrin requires a functional a site. In: Annals of the New York Academy of Sciences. 2001. p. 219–22.
Hogan, K. A., et al. “The formation of beta fibrin requires a functional a site.” Annals of the New York Academy of Sciences, vol. 936, 2001, pp. 219–22. Epmc, doi:10.1111/j.1749-6632.2001.tb03509.x.
Hogan KA, Bolliger B, Okumura N, Lord ST. The formation of beta fibrin requires a functional a site. Annals of the New York Academy of Sciences. 2001. p. 219–222.
Published In
Annals of the New York Academy of Sciences
DOI
EISSN
1749-6632
ISSN
0077-8923
Publication Date
January 2001
Volume
936
Start / End Page
219 / 222
Related Subject Headings
- Recombinant Proteins
- General Science & Technology
- Fibrinogen
- Fibrin