Skip to main content
Journal cover image

Next generation 3D-printed intravaginal ring for prevention of HIV and unintended pregnancy.

Publication ,  Journal Article
Young, IC; Srinivasan, P; Shrivastava, R; Janusziewicz, R; Thorson, A; Cottrell, ML; Sellers, RS; Sykes, C; Schauer, A; Little, D; Kelley, K ...
Published in: Biomaterials
October 2023

Globally, there are 20 million adolescent girls and young women living with HIV who have limited access to long-acting, effective, women-controlled preventative methods. Additionally, although there are many contraceptive methods available, globally, half of all pregnancies remain unintended. Here we report the first 3D-printed multipurpose prevention technology (MPT) intravaginal ring (IVR) for HIV prevention and contraception. We utilized continuous liquid interface production (CLIP™) to fabricate MPT IVRs in a biocompatible silicone-based resin. Etonogestrel (ENG), ethinyl estradiol (EE), and islatravir (ISL) were loaded into the silicone poly(urethane) IVR in a controlled single step drug loading process driven by absorption. ENG/EE/ISL IVR promoted sustained release of drugs for 150 days in vitro and 14 days in sheep. There were no adverse MPT IVR-related findings of cervicovaginal toxicity or changes in vaginal biopsies or microbiome community profiles evaluated in sheep. Furthermore, ISL IVR in macaques promoted sustained release for 28 days with ISL-triphosphate levels above the established pharmacokinetic benchmark of 50-100 fmol/106 PBMCs. The ISL IVR was found to be safe and well tolerated in the macaques with no observed mucosal cytokine changes or alterations in peripheral CD4 T-cell populations. Collectively, the proposed MPT IVR has potential to expand preventative choices for young women and girls.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Biomaterials

DOI

EISSN

1878-5905

ISSN

0142-9612

Publication Date

October 2023

Volume

301

Start / End Page

122260

Related Subject Headings

  • Sheep
  • Printing, Three-Dimensional
  • Pregnancy, Unplanned
  • Pregnancy
  • Macaca
  • Humans
  • HIV Infections
  • Female
  • Delayed-Action Preparations
  • Biomedical Engineering
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Young, I. C., Srinivasan, P., Shrivastava, R., Janusziewicz, R., Thorson, A., Cottrell, M. L., … Benhabbour, S. R. (2023). Next generation 3D-printed intravaginal ring for prevention of HIV and unintended pregnancy. Biomaterials, 301, 122260. https://doi.org/10.1016/j.biomaterials.2023.122260
Young, Isabella C., Priya Srinivasan, Roopali Shrivastava, Rima Janusziewicz, Allison Thorson, Mackenzie L. Cottrell, Rani S. Sellers, et al. “Next generation 3D-printed intravaginal ring for prevention of HIV and unintended pregnancy.Biomaterials 301 (October 2023): 122260. https://doi.org/10.1016/j.biomaterials.2023.122260.
Young IC, Srinivasan P, Shrivastava R, Janusziewicz R, Thorson A, Cottrell ML, et al. Next generation 3D-printed intravaginal ring for prevention of HIV and unintended pregnancy. Biomaterials. 2023 Oct;301:122260.
Young, Isabella C., et al. “Next generation 3D-printed intravaginal ring for prevention of HIV and unintended pregnancy.Biomaterials, vol. 301, Oct. 2023, p. 122260. Epmc, doi:10.1016/j.biomaterials.2023.122260.
Young IC, Srinivasan P, Shrivastava R, Janusziewicz R, Thorson A, Cottrell ML, Sellers RS, Sykes C, Schauer A, Little D, Kelley K, Kashuba ADM, Katz D, Pyles RB, García-Lerma JG, Vincent KL, Smith J, Benhabbour SR. Next generation 3D-printed intravaginal ring for prevention of HIV and unintended pregnancy. Biomaterials. 2023 Oct;301:122260.
Journal cover image

Published In

Biomaterials

DOI

EISSN

1878-5905

ISSN

0142-9612

Publication Date

October 2023

Volume

301

Start / End Page

122260

Related Subject Headings

  • Sheep
  • Printing, Three-Dimensional
  • Pregnancy, Unplanned
  • Pregnancy
  • Macaca
  • Humans
  • HIV Infections
  • Female
  • Delayed-Action Preparations
  • Biomedical Engineering