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Racial Differences in Over-the-Counter Non-steroidal Anti-inflammatory Drug Use Among Individuals at Risk of Adverse Cardiovascular Events.

Publication ,  Journal Article
Benson, KRK; Diamantidis, CJ; Davenport, CA; Sandler, RS; Boulware, LE; Mohottige, D
Published in: J Racial Ethn Health Disparities
August 18, 2023

PURPOSE: Black Americans are disproportionately affected by adverse cardiovascular events (ACEs). Over-the-counter (OTC) non-steroidal anti-inflammatory drugs (NSAIDs) confer increased risk for ACEs, yet racial differences in the use of these products remain understudied. This study sought to determine racial differences in OTC NSAID and high-potency powdered NSAID (HPP-NSAID) use. METHODS AND MATERIALS: This retrospective analysis examined participants at risk of ACEs (defined as those with self-reported hypertension, diabetes, heart disease, or smoking history ≥ 20 years) from the North Carolina Colon Cancer Study, a population-based case-control study. We used multivariable logistic regression models to assess the independent associations of race with any OTC NSAID use, HPP-NSAID use, and regular use of these products. RESULTS: Of the 1286 participants, 585 (45%) reported Black race and 701 (55%) reported non-Black race. Overall, 665 (52%) reported any OTC NSAID use and 204 (16%) reported HPP-NSAID use. Compared to non-Black individuals, Black individuals were more likely to report both any OTC NSAID use (57% versus 48%) and HPP-NSAID use (22% versus 11%). In multivariable analyses, Black (versus non-Black) race was independently associated with higher odds of both NSAID use (OR 1.4, 95% CI (1.1, 1.8)) and HPP-NSAID use (OR 1.8 (1.3, 2.5)). CONCLUSIONS: Black individuals at risk of ACEs had higher odds of any OTC NSAID and HPP-NSAID use than non-Black individuals, after controlling for pain and socio-economic status. Further research is necessary to identify potential mechanisms driving this increased use.

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Published In

J Racial Ethn Health Disparities

DOI

EISSN

2196-8837

Publication Date

August 18, 2023

Location

Switzerland

Related Subject Headings

  • 4206 Public health
  • 1117 Public Health and Health Services
 

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Benson, K. R. K., Diamantidis, C. J., Davenport, C. A., Sandler, R. S., Boulware, L. E., & Mohottige, D. (2023). Racial Differences in Over-the-Counter Non-steroidal Anti-inflammatory Drug Use Among Individuals at Risk of Adverse Cardiovascular Events. J Racial Ethn Health Disparities. https://doi.org/10.1007/s40615-023-01743-x
Benson, Kathryn R. K., Clarissa J. Diamantidis, Clemontina A. Davenport, Robert S. Sandler, L Ebony Boulware, and Dinushika Mohottige. “Racial Differences in Over-the-Counter Non-steroidal Anti-inflammatory Drug Use Among Individuals at Risk of Adverse Cardiovascular Events.J Racial Ethn Health Disparities, August 18, 2023. https://doi.org/10.1007/s40615-023-01743-x.
Benson KRK, Diamantidis CJ, Davenport CA, Sandler RS, Boulware LE, Mohottige D. Racial Differences in Over-the-Counter Non-steroidal Anti-inflammatory Drug Use Among Individuals at Risk of Adverse Cardiovascular Events. J Racial Ethn Health Disparities. 2023 Aug 18;
Benson, Kathryn R. K., et al. “Racial Differences in Over-the-Counter Non-steroidal Anti-inflammatory Drug Use Among Individuals at Risk of Adverse Cardiovascular Events.J Racial Ethn Health Disparities, Aug. 2023. Pubmed, doi:10.1007/s40615-023-01743-x.
Benson KRK, Diamantidis CJ, Davenport CA, Sandler RS, Boulware LE, Mohottige D. Racial Differences in Over-the-Counter Non-steroidal Anti-inflammatory Drug Use Among Individuals at Risk of Adverse Cardiovascular Events. J Racial Ethn Health Disparities. 2023 Aug 18;
Journal cover image

Published In

J Racial Ethn Health Disparities

DOI

EISSN

2196-8837

Publication Date

August 18, 2023

Location

Switzerland

Related Subject Headings

  • 4206 Public health
  • 1117 Public Health and Health Services