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Assessment of proxy-reported responses as predictors of motor and sensory peripheral neuropathy in children with B-lymphoblastic leukemia.
Chemotherapy-induced peripheral neuropathy (CIPN), a common condition in children with acute lymphoblastic leukemia, can be challenging to diagnose. Using data from Children's Oncology Group AALL0932 physical function study, we sought to determine if parent/guardian proxy-reported responses from the Pediatric Outcomes Data Collection Instrument could identify children with motor or sensory CIPN diagnosed by physical/occupational therapists (PT/OT). Four variables moderately discriminated between children with and without motor CIPN (c-index 0.76, 95% confidence interval [CI]: 0.64-0.84), but sensory and optimism-corrected models had weak discrimination (c-index sensory models 0.65, 95% CI: 0.54-0.74). New proxy-report measures are needed to identify children with PT/OT diagnosed CIPN.
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Related Subject Headings
- Quality of Life
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
- Physical Examination
- Peripheral Nervous System Diseases
- Oncology & Carcinogenesis
- Humans
- Child
- Antineoplastic Agents
- 3213 Paediatrics
Citation
![Journal cover image](https://secure.syndetics.com/index.aspx?isbn=/lc.gif&issn=1545-5017&client=dukeuniv)
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Quality of Life
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
- Physical Examination
- Peripheral Nervous System Diseases
- Oncology & Carcinogenesis
- Humans
- Child
- Antineoplastic Agents
- 3213 Paediatrics