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Epilepsy among the older population of sub-Saharan Africa: Analysis of the global burden of disease database.

Publication ,  Journal Article
Gupta, N; Singh, R; Seas, A; Antwi, P; Kaddumukasa, MN; Kakooza Mwesige, A; Kaddumukasa, M; Haglund, MM; Fuller, AT; Koltai, DC; Ukachukwu, A-EK
Published in: Epilepsy Behav
October 2023

INTRODUCTION: Epilepsy is considered one of the most burdensome neurologic diseases by the World Health Organization due to the high risk of morbidity and mortality. Few studies have investigated the epidemiology of idiopathic epilepsy in Sub-Saharan Africa (SSA). This study aims to characterize the disease burden of epilepsy among the older population in SSA via a large international database. METHODS: Descriptive epidemiological data from the Global Burden of Disease (GBD) database was collected for idiopathic epilepsy in all regions of SSA. The "older" population was defined as 55 years of age and above. The variables of interest included mortality, incidence, prevalence, and disability-adjusted life years (DALYs) rates per one hundred thousand populations. RESULTS: The average mortality rate was highest in Western SSA (6.34 per 100,000), and all regions were significantly higher than the global average (p < 0.001). DALYs and incidence rates of idiopathic epilepsy in all regions of SSA were significantly higher than the global averages (p < 0.01). Globally, the older population had a significantly higher mortality rate than the younger population (2.78 vs 1.62, respectively; p < 0.01). The older population had a higher mortality rate than the younger population in each region of SSA (p < 0.01). Conversely, for DALYs, the younger population had a higher disease burden than the older population globally and in each region of SSA (p < 0.01). CONCLUSION: This study is the first to examine the epidemiologic profile of idiopathic epilepsy in the older population in SSA. Our results indicate that, when compared with the global population, older adults in SSA suffer a greater disease burden and mortality. This study reports the immense need for increased resources and awareness regarding epilepsy in the elderly population of Africa.

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Published In

Epilepsy Behav

DOI

EISSN

1525-5069

Publication Date

October 2023

Volume

147

Start / End Page

109402

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • 5203 Clinical and health psychology
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1103 Clinical Sciences
 

Citation

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Gupta, N., Singh, R., Seas, A., Antwi, P., Kaddumukasa, M. N., Kakooza Mwesige, A., … Ukachukwu, A.-E. (2023). Epilepsy among the older population of sub-Saharan Africa: Analysis of the global burden of disease database. Epilepsy Behav, 147, 109402. https://doi.org/10.1016/j.yebeh.2023.109402
Gupta, Nithin, Rohin Singh, Andreas Seas, Prince Antwi, Martin N. Kaddumukasa, Angelina Kakooza Mwesige, Mark Kaddumukasa, et al. “Epilepsy among the older population of sub-Saharan Africa: Analysis of the global burden of disease database.Epilepsy Behav 147 (October 2023): 109402. https://doi.org/10.1016/j.yebeh.2023.109402.
Gupta N, Singh R, Seas A, Antwi P, Kaddumukasa MN, Kakooza Mwesige A, et al. Epilepsy among the older population of sub-Saharan Africa: Analysis of the global burden of disease database. Epilepsy Behav. 2023 Oct;147:109402.
Gupta, Nithin, et al. “Epilepsy among the older population of sub-Saharan Africa: Analysis of the global burden of disease database.Epilepsy Behav, vol. 147, Oct. 2023, p. 109402. Pubmed, doi:10.1016/j.yebeh.2023.109402.
Gupta N, Singh R, Seas A, Antwi P, Kaddumukasa MN, Kakooza Mwesige A, Kaddumukasa M, Haglund MM, Fuller AT, Koltai DC, Ukachukwu A-EK. Epilepsy among the older population of sub-Saharan Africa: Analysis of the global burden of disease database. Epilepsy Behav. 2023 Oct;147:109402.
Journal cover image

Published In

Epilepsy Behav

DOI

EISSN

1525-5069

Publication Date

October 2023

Volume

147

Start / End Page

109402

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • 5203 Clinical and health psychology
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1103 Clinical Sciences