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The First Collective Examination of Immunosuppressive Practices Among American Intestinal Transplant Centers.

Publication ,  Journal Article
Weiner, J; Llore, N; Ormsby, D; Fujiki, M; Segovia, MC; Obri, M; Jafri, S-M; Liggett, J; Kroemer, AHK; Matsumoto, C; Moon, J; Di Cocco, P ...
Published in: Transplant Direct
September 2023

BACKGROUND: Unlike other solid organs, no standardized treatment algorithms exist for intestinal transplantation (ITx). We established a consortium of American ITx centers to evaluate current practices. METHODS: All American centers performing ITx during the past 3 y were invited to participate. As a consortium, we generated questions to evaluate and collect data from each institution. The data were compiled and analyzed. RESULTS: Ten centers participated, performing 211 ITx during the past 3 y (range, 3-46; mean 21.1). Induction regimens varied widely. Thymoglobulin was the most common, used in the plurality of patients (85/211; 40.3%), but there was no consensus regimen. Similarly, regimens for the treatment of acute cellular rejection, antibody-mediated rejection, and graft-versus-host disease varied significantly between centers. We also evaluated differences in maintenance immunosuppression protocols, desensitization regimens, mammalian target of rapamycin use, antimetabolite use, and posttransplantation surveillance practices. Maintenance tacrolimus levels, stoma presence, and scoping frequency were not associated with differences in rejection events. Definitive association between treatments and outcomes, including graft and patient survival, was not the intention of this initial collaboration and is prevented by the lack of patient-level data and the presence of confounders. However, we identified trends regarding rejection episodes after various induction strategies that require further investigation in our subsequent collaborations. CONCLUSIONS: This initial collaboration reveals the extreme heterogeneity of practices among American ITx centers. Future collaboration will explore patient-level data, stratified by age and transplant type (isolated intestine versus multivisceral), to explore the association between treatment regimens and outcomes.

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Published In

Transplant Direct

DOI

ISSN

2373-8731

Publication Date

September 2023

Volume

9

Issue

9

Start / End Page

e1512

Location

United States

Related Subject Headings

  • 3204 Immunology
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
 

Citation

APA
Chicago
ICMJE
MLA
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Weiner, J., Llore, N., Ormsby, D., Fujiki, M., Segovia, M. C., Obri, M., … Reyes, J. (2023). The First Collective Examination of Immunosuppressive Practices Among American Intestinal Transplant Centers. Transplant Direct, 9(9), e1512. https://doi.org/10.1097/TXD.0000000000001512
Weiner, Joshua, Nathaly Llore, Dylan Ormsby, Masato Fujiki, Maria Cristina Segovia, Mark Obri, Syed-Mohammed Jafri, et al. “The First Collective Examination of Immunosuppressive Practices Among American Intestinal Transplant Centers.Transplant Direct 9, no. 9 (September 2023): e1512. https://doi.org/10.1097/TXD.0000000000001512.
Weiner J, Llore N, Ormsby D, Fujiki M, Segovia MC, Obri M, et al. The First Collective Examination of Immunosuppressive Practices Among American Intestinal Transplant Centers. Transplant Direct. 2023 Sep;9(9):e1512.
Weiner, Joshua, et al. “The First Collective Examination of Immunosuppressive Practices Among American Intestinal Transplant Centers.Transplant Direct, vol. 9, no. 9, Sept. 2023, p. e1512. Pubmed, doi:10.1097/TXD.0000000000001512.
Weiner J, Llore N, Ormsby D, Fujiki M, Segovia MC, Obri M, Jafri S-M, Liggett J, Kroemer AHK, Matsumoto C, Moon J, Di Cocco P, Selvaggi G, Garcia J, Ganoza A, Khanna A, Mazariegos G, Wendel D, Reyes J. The First Collective Examination of Immunosuppressive Practices Among American Intestinal Transplant Centers. Transplant Direct. 2023 Sep;9(9):e1512.

Published In

Transplant Direct

DOI

ISSN

2373-8731

Publication Date

September 2023

Volume

9

Issue

9

Start / End Page

e1512

Location

United States

Related Subject Headings

  • 3204 Immunology
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology