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Common Issues in Breast Cancer Survivors: A Practical Guide to Evaluation and Management

Arthralgias

Publication ,  Chapter
Kimmick, GG; Pienknagura, RA; Weinmann, SC
January 1, 2021

Musculoskeletal and joint pain are common in women, especially in perimenopausal and aging women. In women diagnosed with breast cancer, cancer treatment can be associated with musculoskeletal symptoms, particularly arthralgia, or non-inflammatory joint pain. Evaluation of new-onset arthralgia should include the history, physical examination, and laboratory evaluation for common non-inflammatory and inflammatory causes of joint pain. After chemotherapy, the self-limited syndrome of post-chemotherapy rheumatism may develop within 3–4 months of treatment and can last several months before it subsides. This syndrome may overlap with the start of adjuvant endocrine therapy, which may also be associated with arthralgia, particularly endocrine therapy with aromatase inhibitors. Aromatase inhibitor-associated arthralgia (AIAA) is common and difficult to treat. Regular exercise and adequate vitamin D levels can alleviate arthralgia and are also associated with improved well-being and better breast cancer and overall outcomes. Other approaches to relieve AIAA include switching to another endocrine therapy, use of a complementary intervention (like acupuncture or a supplement), and duloxetine. In cases where inflammatory arthritis is suspected or arthralgia is more persistent or severe than is typical for AIAA, referral to a rheumatologist is warranted.

Duke Scholars

DOI

ISBN

9783030753764

Publication Date

January 1, 2021

Start / End Page

85 / 104
 

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Kimmick, G. G., Pienknagura, R. A., & Weinmann, S. C. (2021). Arthralgias. In Common Issues in Breast Cancer Survivors: A Practical Guide to Evaluation and Management (pp. 85–104). https://doi.org/10.1007/978-3-030-75377-1_6
Kimmick, G. G., R. A. Pienknagura, and S. C. Weinmann. “Arthralgias.” In Common Issues in Breast Cancer Survivors: A Practical Guide to Evaluation and Management, 85–104, 2021. https://doi.org/10.1007/978-3-030-75377-1_6.
Kimmick GG, Pienknagura RA, Weinmann SC. Arthralgias. In: Common Issues in Breast Cancer Survivors: A Practical Guide to Evaluation and Management. 2021. p. 85–104.
Kimmick, G. G., et al. “Arthralgias.” Common Issues in Breast Cancer Survivors: A Practical Guide to Evaluation and Management, 2021, pp. 85–104. Scopus, doi:10.1007/978-3-030-75377-1_6.
Kimmick GG, Pienknagura RA, Weinmann SC. Arthralgias. Common Issues in Breast Cancer Survivors: A Practical Guide to Evaluation and Management. 2021. p. 85–104.
Journal cover image

DOI

ISBN

9783030753764

Publication Date

January 1, 2021

Start / End Page

85 / 104