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Influence of Race/Ethnicity and Sex on Coronary Stent Outcomes in Diabetic Patients

Publication ,  Journal Article
Epps, K; Goel, R; Mehran, R; Kandzari, D; Damluji, A; Tehrani, B; Sherwood, M; Truesdell, A; Davis, S; Wang, JC; Lopez, M; Singh, S ...
Published in: Journal of the Society for Cardiovascular Angiography and Interventions
September 1, 2023

Background: How diabetes mellitus (DM), race/ethnicity, and sex impact ischemic events following coronary artery stent procedures is unknown. Methods: Using the PLATINUM Diversity and PROMUS Element Plus Post-Approval Pooled Study (N = 4184), we examined the impact of race/ethnicity, sex, and DM on coronary stent outcomes. Primary outcome was 1-year major adverse cardiac events (MACE) (MACE composite: death, myocardial infarction [MI], and target vessel revascularization). Results: The study sample included 1437 diabetic patients (501 White men, 470 White women, 246 minority men, 220 minority women) and 2641 patients without medically treated DM (561 minority, 1090 women). Mean age (years) ranged from 61 in minority men to 65 in White women. Diabetic patients had a higher prevalence of atherosclerotic risk factors and comorbidities. Diabetic minority women (DMW; 70% Black, 27% Hispanic) had similar atherosclerotic risk factors to other diabetics, but experienced higher 1-year MACE (14.4% vs 7.5%, P < .01) and MI (4.3% vs 1.6%, P < .01) rates compared with patients without medically treated DM. No other diabetic cohort (White men, White women, minority men) showed an increased risk of MACE vs patients without medically treated DM. The incremental risk of MACE in DMW was associated with insulin use and persisted after risk adjustment (adjusted odds ratio 1.6 vs patients without medically treated DM; 95% CI, 1.0-2.5). Independent predictors of 1-year MACE included insulin use, hyperlipidemia, renal disease, and prior MI. Conclusions: DMW face the highest risk of ischemic events following coronary stenting, driven, in part, by insulin use. Aggressive secondary prevention and strict glycemic control are imperative in this cohort, and further research is warranted to elucidate the biologic mechanisms underpinning these observations.

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Published In

Journal of the Society for Cardiovascular Angiography and Interventions

DOI

EISSN

2772-9303

Publication Date

September 1, 2023

Volume

2

Issue

5
 

Citation

APA
Chicago
ICMJE
MLA
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Epps, K., Goel, R., Mehran, R., Kandzari, D., Damluji, A., Tehrani, B., … Batchelor, W. (2023). Influence of Race/Ethnicity and Sex on Coronary Stent Outcomes in Diabetic Patients. Journal of the Society for Cardiovascular Angiography and Interventions, 2(5). https://doi.org/10.1016/j.jscai.2023.101053
Epps, K., R. Goel, R. Mehran, D. Kandzari, A. Damluji, B. Tehrani, M. Sherwood, et al. “Influence of Race/Ethnicity and Sex on Coronary Stent Outcomes in Diabetic Patients.” Journal of the Society for Cardiovascular Angiography and Interventions 2, no. 5 (September 1, 2023). https://doi.org/10.1016/j.jscai.2023.101053.
Epps K, Goel R, Mehran R, Kandzari D, Damluji A, Tehrani B, et al. Influence of Race/Ethnicity and Sex on Coronary Stent Outcomes in Diabetic Patients. Journal of the Society for Cardiovascular Angiography and Interventions. 2023 Sep 1;2(5).
Epps, K., et al. “Influence of Race/Ethnicity and Sex on Coronary Stent Outcomes in Diabetic Patients.” Journal of the Society for Cardiovascular Angiography and Interventions, vol. 2, no. 5, Sept. 2023. Scopus, doi:10.1016/j.jscai.2023.101053.
Epps K, Goel R, Mehran R, Kandzari D, Damluji A, Tehrani B, Sherwood M, Truesdell A, Davis S, Wang JC, Lopez M, Singh S, Underwood P, Allocco D, Batchelor W. Influence of Race/Ethnicity and Sex on Coronary Stent Outcomes in Diabetic Patients. Journal of the Society for Cardiovascular Angiography and Interventions. 2023 Sep 1;2(5).

Published In

Journal of the Society for Cardiovascular Angiography and Interventions

DOI

EISSN

2772-9303

Publication Date

September 1, 2023

Volume

2

Issue

5