A role for the cortex in sleep-wake regulation.
Publication
, Journal Article
Krone, LB; Yamagata, T; Blanco-Duque, C; Guillaumin, MCC; Kahn, MC; van der Vinne, V; McKillop, LE; Tam, SKE; Peirson, SN; Akerman, CJ ...
Published in: Nature neuroscience
September 2021
Cortical and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global state control, respectively. Here we silenced a subset of neocortical layer 5 pyramidal and archicortical dentate gyrus granule cells in male mice by ablating SNAP25. This markedly increased wakefulness and reduced rebound of electroencephalographic slow-wave activity after sleep deprivation, suggesting a role for the cortex in both vigilance state control and sleep homeostasis.
Duke Scholars
Published In
Nature neuroscience
DOI
EISSN
1546-1726
ISSN
1097-6256
Publication Date
September 2021
Volume
24
Issue
9
Start / End Page
1210 / 1215
Related Subject Headings
- Wakefulness
- Synaptosomal-Associated Protein 25
- Sleep
- Neurons
- Neurology & Neurosurgery
- Neocortex
- Mice, Transgenic
- Mice
- Male
- Dentate Gyrus
Citation
APA
Chicago
ICMJE
MLA
NLM
Krone, L. B., Yamagata, T., Blanco-Duque, C., Guillaumin, M. C. C., Kahn, M. C., van der Vinne, V., … Vyazovskiy, V. V. (2021). A role for the cortex in sleep-wake regulation. Nature Neuroscience, 24(9), 1210–1215. https://doi.org/10.1038/s41593-021-00894-6
Krone, Lukas B., Tomoko Yamagata, Cristina Blanco-Duque, Mathilde C. C. Guillaumin, Martin C. Kahn, Vincent van der Vinne, Laura E. McKillop, et al. “A role for the cortex in sleep-wake regulation.” Nature Neuroscience 24, no. 9 (September 2021): 1210–15. https://doi.org/10.1038/s41593-021-00894-6.
Krone LB, Yamagata T, Blanco-Duque C, Guillaumin MCC, Kahn MC, van der Vinne V, et al. A role for the cortex in sleep-wake regulation. Nature neuroscience. 2021 Sep;24(9):1210–5.
Krone, Lukas B., et al. “A role for the cortex in sleep-wake regulation.” Nature Neuroscience, vol. 24, no. 9, Sept. 2021, pp. 1210–15. Epmc, doi:10.1038/s41593-021-00894-6.
Krone LB, Yamagata T, Blanco-Duque C, Guillaumin MCC, Kahn MC, van der Vinne V, McKillop LE, Tam SKE, Peirson SN, Akerman CJ, Hoerder-Suabedissen A, Molnár Z, Vyazovskiy VV. A role for the cortex in sleep-wake regulation. Nature neuroscience. 2021 Sep;24(9):1210–1215.
Published In
Nature neuroscience
DOI
EISSN
1546-1726
ISSN
1097-6256
Publication Date
September 2021
Volume
24
Issue
9
Start / End Page
1210 / 1215
Related Subject Headings
- Wakefulness
- Synaptosomal-Associated Protein 25
- Sleep
- Neurons
- Neurology & Neurosurgery
- Neocortex
- Mice, Transgenic
- Mice
- Male
- Dentate Gyrus