Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Comparative outcomes of middle meningeal artery embolization with statins versus embolization alone in the treatment of chronic subdural hematoma: a systematic review and meta-analysis.

Publication ,  Journal Article
Musmar, B; Spellicy, S; Salim, H; Abdelgadir, J; Zomorodi, A; Cutler, A; Jabbour, P; Hasan, D
Published in: Neurosurg Rev
October 3, 2023

Chronic subdural hematoma (cSDH) is common among the elderly, with surgical evacuation as a prevalent treatment, facing recurrence rates up to 30%. Recently, middle meningeal artery embolization (MMAE) has emerged as a promising approach, offering reduced treatment failures and recurrence rates. Additionally, statins, known for their anti-inflammatory properties, have been considered as a potential adjunctive or sole treatment for cSDH. However, the combination of MMAE with statins remains understudied. This systematic review and meta-analysis aims to evaluate the comparative outcomes of MMAE with statins versus MMAE alone in the treatment of cSDH. A comprehensive systematic search of the PubMed, Web of Science, and SCOPUS databases was conducted. Inclusion criteria were: studies published in English between the dates of inception of each database and August 2023, studies comparing the treatment of cSDH with either MMAE + statin or MMAE alone were included. Main outcome measures were complete resolution of the hematoma at follow-up and the recurrence rates. Two studies comprising 715 patients were included; 408 patients underwent MMAE + statin; and 307 underwent MMAE alone. MMAE + statin was not significantly superior to MMAE alone in achieving complete resolution of the hematoma at follow-up (RR: 0.99; CI: 0.91 to 1.07, P = 0.84), nor was it a significant difference in rates of recurrence (RR: 1.35; CI: 0.83 to 2.17, P = 0.21) between the two groups. MMAE + statin did not demonstrate significant superiority over MMAE alone for achieving complete resolution and decreasing the recurrence rates in cSDH patients. Further research with larger, randomized studies may be required to fully elucidate the potential synergistic effects of MMAE and statins in this patient population.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Neurosurg Rev

DOI

EISSN

1437-2320

Publication Date

October 3, 2023

Volume

46

Issue

1

Start / End Page

262

Location

Germany

Related Subject Headings

  • Neurology & Neurosurgery
  • Meningeal Arteries
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • Hematoma, Subdural, Chronic
  • Hematoma
  • Embolization, Therapeutic
  • Aged
  • 3209 Neurosciences
  • 3203 Dentistry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Musmar, B., Spellicy, S., Salim, H., Abdelgadir, J., Zomorodi, A., Cutler, A., … Hasan, D. (2023). Comparative outcomes of middle meningeal artery embolization with statins versus embolization alone in the treatment of chronic subdural hematoma: a systematic review and meta-analysis. Neurosurg Rev, 46(1), 262. https://doi.org/10.1007/s10143-023-02165-3
Musmar, Basel, Samantha Spellicy, Hamza Salim, Jihad Abdelgadir, Ali Zomorodi, Andrew Cutler, Pascal Jabbour, and David Hasan. “Comparative outcomes of middle meningeal artery embolization with statins versus embolization alone in the treatment of chronic subdural hematoma: a systematic review and meta-analysis.Neurosurg Rev 46, no. 1 (October 3, 2023): 262. https://doi.org/10.1007/s10143-023-02165-3.
Musmar B, Spellicy S, Salim H, Abdelgadir J, Zomorodi A, Cutler A, Jabbour P, Hasan D. Comparative outcomes of middle meningeal artery embolization with statins versus embolization alone in the treatment of chronic subdural hematoma: a systematic review and meta-analysis. Neurosurg Rev. 2023 Oct 3;46(1):262.
Journal cover image

Published In

Neurosurg Rev

DOI

EISSN

1437-2320

Publication Date

October 3, 2023

Volume

46

Issue

1

Start / End Page

262

Location

Germany

Related Subject Headings

  • Neurology & Neurosurgery
  • Meningeal Arteries
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • Hematoma, Subdural, Chronic
  • Hematoma
  • Embolization, Therapeutic
  • Aged
  • 3209 Neurosciences
  • 3203 Dentistry