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UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology.

Publication ,  Journal Article
Price, MJ; Nguyen, AD; Byemerwa, JK; Flowers, J; Baëta, CD; Goodwin, CR
Published in: Oncotarget
September 28, 2023

UDP-glucose-6-dehydrogenase (UGDH) is a cytosolic, hexameric enzyme that converts UDP-glucose to UDP-glucuronic acid (UDP-GlcUA), a key reaction in hormone and xenobiotic metabolism and in the production of extracellular matrix precursors. In this review, we classify UGDH as a molecular indicator of tumor progression in multiple cancer types, describe its involvement in key canonical cancer signaling pathways, and identify methods to inhibit UGDH, its substrates, and its downstream products. As such, we position UGDH as an enzyme to be exploited as a potential prognostication marker in oncology and a therapeutic target in cancer biology.

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Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

September 28, 2023

Volume

14

Start / End Page

843 / 857

Location

United States

Related Subject Headings

  • Uridine Diphosphate Glucose Dehydrogenase
  • Uridine Diphosphate Glucose
  • Neoplasms
  • Medical Oncology
  • Humans
  • Glucose Dehydrogenases
  • Glucose
  • Biology
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

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Price, M. J., Nguyen, A. D., Byemerwa, J. K., Flowers, J., Baëta, C. D., & Goodwin, C. R. (2023). UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology. Oncotarget, 14, 843–857. https://doi.org/10.18632/oncotarget.28514
Price, Meghan J., Annee D. Nguyen, Jovita K. Byemerwa, Jasmine Flowers, César D. Baëta, and C Rory Goodwin. “UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology.Oncotarget 14 (September 28, 2023): 843–57. https://doi.org/10.18632/oncotarget.28514.
Price MJ, Nguyen AD, Byemerwa JK, Flowers J, Baëta CD, Goodwin CR. UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology. Oncotarget. 2023 Sep 28;14:843–57.
Price, Meghan J., et al. “UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology.Oncotarget, vol. 14, Sept. 2023, pp. 843–57. Pubmed, doi:10.18632/oncotarget.28514.
Price MJ, Nguyen AD, Byemerwa JK, Flowers J, Baëta CD, Goodwin CR. UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology. Oncotarget. 2023 Sep 28;14:843–857.

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

September 28, 2023

Volume

14

Start / End Page

843 / 857

Location

United States

Related Subject Headings

  • Uridine Diphosphate Glucose Dehydrogenase
  • Uridine Diphosphate Glucose
  • Neoplasms
  • Medical Oncology
  • Humans
  • Glucose Dehydrogenases
  • Glucose
  • Biology
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis