Utilization of Machine Perfusion and Nanotechnology for Liver Transplantation

Over the past four decades, advances in the technology supporting solid organ transplantation have been remarkable. Transplantation is now entering a new era where multidisciplinary approaches, including the use of bioengineering, are being utilized in the pursuit of perfection for the field. In this review article, we will introduce and recap two broad categories that are on the verge of revolutionizing the utilization of donor organs and delivery of immunosuppression, metabolic additives, and gene therapies. Machine perfusion techniques and nanotechnology are areas of significant interest in the transplantation community and make up the next generation of bench to bedside research endeavors. In this review, we will summarize the progress made in the field of machine perfusion and nanotechnology as it applies to liver transplantation.

Duke Scholars

Author Kunal Patel Surgery, Cardiovascular and Thoracic Surgery