The DNA secondary structures at telomeres and genome instability
Publication
, Journal Article
Tan, J; Lan, L
Published in: Cell and Bioscience
March 26, 2020
Telomeric DNA are TTAGGG tandem repeats, which are susceptible for oxidative DNA damage and hotspot regions for formation of DNA secondary structures such as t-loop, D-loop, G-quadruplexes (G4), and R-loop. In the past two decades, unique DNA or RNA secondary structures at telomeres or some specific regions of genome have become promising therapeutic targets. G-quadruplex and R-loops at telomeres or transcribed regions of genome have been considered as the potential targets for cancer therapy. Here we discuss the potentials to target the secondary structures (G4s and R-loops) in genome as therapy approaches.
Duke Scholars
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Published In
Cell and Bioscience
DOI
EISSN
2045-3701
Publication Date
March 26, 2020
Volume
10
Issue
1
Citation
APA
Chicago
ICMJE
MLA
NLM
Tan, J., & Lan, L. (2020). The DNA secondary structures at telomeres and genome instability. Cell and Bioscience, 10(1). https://doi.org/10.1186/s13578-020-00409-z
Tan, J., and L. Lan. “The DNA secondary structures at telomeres and genome instability.” Cell and Bioscience 10, no. 1 (March 26, 2020). https://doi.org/10.1186/s13578-020-00409-z.
Tan J, Lan L. The DNA secondary structures at telomeres and genome instability. Cell and Bioscience. 2020 Mar 26;10(1).
Tan, J., and L. Lan. “The DNA secondary structures at telomeres and genome instability.” Cell and Bioscience, vol. 10, no. 1, Mar. 2020. Scopus, doi:10.1186/s13578-020-00409-z.
Tan J, Lan L. The DNA secondary structures at telomeres and genome instability. Cell and Bioscience. 2020 Mar 26;10(1).
Published In
Cell and Bioscience
DOI
EISSN
2045-3701
Publication Date
March 26, 2020
Volume
10
Issue
1