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Deciphering Genomic Underpinnings of Quantitative MRI-based Radiomic Phenotypes of Invasive Breast Carcinoma.

Publication ,  Journal Article
Zhu, Y; Li, H; Guo, W; Drukker, K; Lan, L; Giger, ML; Ji, Y
Published in: Sci Rep
December 7, 2015

Magnetic Resonance Imaging (MRI) has been routinely used for the diagnosis and treatment of breast cancer. However, the relationship between the MRI tumor phenotypes and the underlying genetic mechanisms remains under-explored. We integrated multi-omics molecular data from The Cancer Genome Atlas (TCGA) with MRI data from The Cancer Imaging Archive (TCIA) for 91 breast invasive carcinomas. Quantitative MRI phenotypes of tumors (such as tumor size, shape, margin, and blood flow kinetics) were associated with their corresponding molecular profiles (including DNA mutation, miRNA expression, protein expression, pathway gene expression and copy number variation). We found that transcriptional activities of various genetic pathways were positively associated with tumor size, blurred tumor margin, and irregular tumor shape and that miRNA expressions were associated with the tumor size and enhancement texture, but not with other types of radiomic phenotypes. We provide all the association findings as a resource for the research community (available at http://compgenome.org/Radiogenomics/). These findings pave potential paths for the discovery of genetic mechanisms regulating specific tumor phenotypes and for improving MRI techniques as potential non-invasive approaches to probe the cancer molecular status.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

December 7, 2015

Volume

5

Start / End Page

17787

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Radiography
  • Phenotype
  • Neoplasm Invasiveness
  • Mutation
  • MicroRNAs
  • Magnetic Resonance Imaging
  • Humans
  • Genome, Human
  • Genetic Association Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhu, Y., Li, H., Guo, W., Drukker, K., Lan, L., Giger, M. L., & Ji, Y. (2015). Deciphering Genomic Underpinnings of Quantitative MRI-based Radiomic Phenotypes of Invasive Breast Carcinoma. Sci Rep, 5, 17787. https://doi.org/10.1038/srep17787
Zhu, Yitan, Hui Li, Wentian Guo, Karen Drukker, Li Lan, Maryellen L. Giger, and Yuan Ji. “Deciphering Genomic Underpinnings of Quantitative MRI-based Radiomic Phenotypes of Invasive Breast Carcinoma.Sci Rep 5 (December 7, 2015): 17787. https://doi.org/10.1038/srep17787.
Zhu Y, Li H, Guo W, Drukker K, Lan L, Giger ML, et al. Deciphering Genomic Underpinnings of Quantitative MRI-based Radiomic Phenotypes of Invasive Breast Carcinoma. Sci Rep. 2015 Dec 7;5:17787.
Zhu, Yitan, et al. “Deciphering Genomic Underpinnings of Quantitative MRI-based Radiomic Phenotypes of Invasive Breast Carcinoma.Sci Rep, vol. 5, Dec. 2015, p. 17787. Pubmed, doi:10.1038/srep17787.
Zhu Y, Li H, Guo W, Drukker K, Lan L, Giger ML, Ji Y. Deciphering Genomic Underpinnings of Quantitative MRI-based Radiomic Phenotypes of Invasive Breast Carcinoma. Sci Rep. 2015 Dec 7;5:17787.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

December 7, 2015

Volume

5

Start / End Page

17787

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Radiography
  • Phenotype
  • Neoplasm Invasiveness
  • Mutation
  • MicroRNAs
  • Magnetic Resonance Imaging
  • Humans
  • Genome, Human
  • Genetic Association Studies