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Computerized assessment of motion-contaminated calcified plaques in cardiac multidetector CT.

Publication ,  Journal Article
King, M; Giger, ML; Suzuki, K; Bardo, DME; Greenberg, B; Lan, L; Pan, X
Published in: Med Phys
December 2007

An automated method for evaluating the image quality of calcified plaques with respect to motion artifacts in noncontrast-enhanced cardiac computed tomography (CT) images is introduced. This method involves using linear regression (LR) and artificial neural network (ANN) regression models for predicting two patient-specific, region-of-interest-specific, reconstruction-specific and temporal phase-specific image quality indices. The first is a plaque motion index, which is derived from the actual trajectory of the calcified plaque and is represented on a continuous scale. The second is an assessability index, which reflects the degree to which a calcified plaque is affected by motion artifacts, and is represented on an ordinal five-point scale. Two sets of assessability indices were provided independently by two radiologists experienced in evaluating cardiac CT images. Inputs for the regression models were selected from 12 features characterizing the dynamic, morphological, and intensity-based properties of the calcified plaques. Whereas LR-velocity (LR-V) used only a single feature (three-dimensional velocity), the LR-multiple (LR-M) and ANN regression models used the same subset of these 12 features selected through stepwise regression. The regression models were parameterized and evaluated using a database of simulated calcified plaque images from the dynamic NCAT phantom involving nine heart rate/multi-sector gating combinations and 40 cardiac phases covering two cardiac cycles. Six calcified plaques were used for the plaque motion indices and three calcified plaques were used for both sets of assessability indices. In one configuration, images from the second cardiac cycle were used for feature selection and regression model parameterization, whereas images from the first cardiac cycle were used for testing. With this configuration, repeated measures concordance correlation coefficients (CCCs) and associated 95% confidence intervals for the LR-V, LR-M, and ANN were 0.817 [0.785, 0.848], 0.894 [0.869, 0.916], and 0.917 [0.892, 0.936] for the plaque motion indices. For the two sets of assess-ability indices, CCC values for the ANN model were 0.843 [0.791, 0.877] and 0.793 [0.747, 0.828]. These two CCC values were statistically greater than the CCC value of 0.689 [0.648, 0.727], which was obtained by comparing the two sets of assessability indices with each other. These preliminary results suggest that the variabilities of assessability indices provided by regression models can lie within the variabilities of the indices assigned by independent observers. Thus, the potential exists for using regression models and assessability indices for determining optimal phases for cardiac CT image interpretation.

Duke Scholars

Published In

Med Phys

DOI

ISSN

0094-2405

Publication Date

December 2007

Volume

34

Issue

12

Start / End Page

4876 / 4889

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Nuclear Medicine & Medical Imaging
  • Neural Networks, Computer
  • Myocardium
  • Movement
  • Linear Models
  • Humans
  • Heart
  • Calcinosis
  • Atherosclerosis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
King, M., Giger, M. L., Suzuki, K., Bardo, D. M. E., Greenberg, B., Lan, L., & Pan, X. (2007). Computerized assessment of motion-contaminated calcified plaques in cardiac multidetector CT. Med Phys, 34(12), 4876–4889. https://doi.org/10.1118/1.2804718
King, Martin, Maryellen L. Giger, Kenji Suzuki, Dianna M. E. Bardo, Brent Greenberg, Li Lan, and Xiaochuan Pan. “Computerized assessment of motion-contaminated calcified plaques in cardiac multidetector CT.Med Phys 34, no. 12 (December 2007): 4876–89. https://doi.org/10.1118/1.2804718.
King M, Giger ML, Suzuki K, Bardo DME, Greenberg B, Lan L, et al. Computerized assessment of motion-contaminated calcified plaques in cardiac multidetector CT. Med Phys. 2007 Dec;34(12):4876–89.
King, Martin, et al. “Computerized assessment of motion-contaminated calcified plaques in cardiac multidetector CT.Med Phys, vol. 34, no. 12, Dec. 2007, pp. 4876–89. Pubmed, doi:10.1118/1.2804718.
King M, Giger ML, Suzuki K, Bardo DME, Greenberg B, Lan L, Pan X. Computerized assessment of motion-contaminated calcified plaques in cardiac multidetector CT. Med Phys. 2007 Dec;34(12):4876–4889.

Published In

Med Phys

DOI

ISSN

0094-2405

Publication Date

December 2007

Volume

34

Issue

12

Start / End Page

4876 / 4889

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Nuclear Medicine & Medical Imaging
  • Neural Networks, Computer
  • Myocardium
  • Movement
  • Linear Models
  • Humans
  • Heart
  • Calcinosis
  • Atherosclerosis