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Computerized three-class classification of MRI-based prognostic markers for breast cancer.
The purpose of this study is to investigate whether computerized analysis using three-class Bayesian artificial neural network (BANN) feature selection and classification can characterize tumor grades (grade 1, grade 2 and grade 3) of breast lesions for prognostic classification on DCE-MRI. A database of 26 IDC grade 1 lesions, 86 IDC grade 2 lesions and 58 IDC grade 3 lesions was collected. The computer automatically segmented the lesions, and kinetic and morphological lesion features were automatically extracted. The discrimination tasks-grade 1 versus grade 3, grade 2 versus grade 3, and grade 1 versus grade 2 lesions-were investigated. Step-wise feature selection was conducted by three-class BANNs. Classification was performed with three-class BANNs using leave-one-lesion-out cross-validation to yield computer-estimated probabilities of being grade 3 lesion, grade 2 lesion and grade 1 lesion. Two-class ROC analysis was used to evaluate the performances. We achieved AUC values of 0.80 ± 0.05, 0.78 ± 0.05 and 0.62 ± 0.05 for grade 1 versus grade 3, grade 1 versus grade 2, and grade 2 versus grade 3, respectively. This study shows the potential for (1) applying three-class BANN feature selection and classification to CADx and (2) expanding the role of DCE-MRI CADx from diagnostic to prognostic classification in distinguishing tumor grades.
Duke Scholars
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Related Subject Headings
- Radionuclide Imaging
- Radiographic Image Interpretation, Computer-Assisted
- ROC Curve
- Pattern Recognition, Automated
- Nuclear Medicine & Medical Imaging
- Neoplasm Grading
- Magnetic Resonance Imaging
- Humans
- Female
- Breast Neoplasms
Citation
![Journal cover image](https://secure.syndetics.com/index.aspx?isbn=/lc.gif&issn=1361-6560&client=dukeuniv)
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Radionuclide Imaging
- Radiographic Image Interpretation, Computer-Assisted
- ROC Curve
- Pattern Recognition, Automated
- Nuclear Medicine & Medical Imaging
- Neoplasm Grading
- Magnetic Resonance Imaging
- Humans
- Female
- Breast Neoplasms