Ambient particulate matter pollution of different sizes associated with recurrent stroke hospitalization in China: A cohort study of 1.07 million stroke patients.

To estimate the associations between ambient particulate matter (PM) pollution of different sizes (PM₁, PM_2.5, and PM₁₀) and risk of rehospitalization among stroke patients, as well as the attributable burden in China.We built a cohort of 1,066,752 participants with an index stroke hospitalization in Sichuan, China from 2017 to 2019. Seven-day and annual average exposures to PM pollution prior to the date of the index hospitalization were linked with residential address using a bilinear interpolation approach. Cox proportional hazard models were constructed to assess the association between ambient PM and the risk of rehospitalization. The burden of stroke rehospitalization was estimated using a counterfactual approach.245,457 (23.0 %) participants experienced rehospitalization during a mean of 1.15 years (SD: 0.90 years) of follow-up. Seven-day average concentrations of PM were associated with increased risk of rehospitalization: the hazard ratios (HRs) per 10 μg/m³ were 1.034 (95 % confidence interval [CI]: 1.029-1.038) for PM₁, 1.033 (1.031-1.036) for PM_2.5, and 1.030 (1.028-1.031) for PM₁₀; the hazard ratios were larger for annual average concentrations: 1.082 (1.074-1.090) for PM₁, 1.109 (1.104-1.114) for PM_2.5, and 1.103 (1.099-1.106) for PM₁₀. The associations were stronger in participants who were female, of minority ethnicity (non-Han Chinese), who suffered from an ischemic stroke, and those admitted under normal conditions. Population attributable fractions for stroke rehospitalization ranged from 4.66 % (95 % CI: 1.69 % to 7.63 %) for the 7-day average of PM₁ to 17.05 % (14.27 % to 19.83 %) for the annual average of PM₁₀; the reducible average cost of rehospitalization per participant attributable to PM ranged from 492.09 (178.19 to 806) RMB for the 7-day average of PM₁ to 1801.65 (1507.89 to 2095.41) RMB for the annual average of PM₁₀.Ambient PM pollution may increase the risk of rehospitalization in stroke patients and is responsible for a significant burden of stroke rehospitalization.

Duke Scholars

Author Shiyu Zhang