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Plasma Proteomics of COVID-19–Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics

Publication ,  Journal Article
Roh, JD; Kitchen, RR; Guseh, JS; McNeill, JN; Aid, M; Martinot, AJ; Yu, A; Platt, C; Rhee, J; Weber, B; Trager, LE; Hastings, MH; Ducat, S ...
Published in: JACC: Basic to Translational Science
May 1, 2022

To gain insights into the mechanisms driving cardiovascular complications in COVID-19, we performed a case-control plasma proteomics study in COVID-19 patients. Our results identify the senescence-associated secretory phenotype, a marker of biological aging, as the dominant process associated with disease severity and cardiac involvement. FSTL3, an indicator of senescence-promoting Activin/TGFβ signaling, and ADAMTS13, the von Willebrand Factor–cleaving protease whose loss-of-function causes microvascular thrombosis, were among the proteins most strongly associated with myocardial stress and injury. Findings were validated in a larger COVID-19 patient cohort and the hamster COVID-19 model, providing new insights into the pathophysiology of COVID-19 cardiovascular complications with therapeutic implications.

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Published In

JACC: Basic to Translational Science

DOI

ISSN

2452-302X

Publication Date

May 1, 2022

Volume

7

Issue

5

Start / End Page

425 / 441

Related Subject Headings

  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology
 

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Roh, J. D., Kitchen, R. R., Guseh, J. S., McNeill, J. N., Aid, M., Martinot, A. J., … Rosenzweig, A. (2022). Plasma Proteomics of COVID-19–Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics. JACC: Basic to Translational Science, 7(5), 425–441. https://doi.org/10.1016/j.jacbts.2022.01.013
Roh, J. D., R. R. Kitchen, J. S. Guseh, J. N. McNeill, M. Aid, A. J. Martinot, A. Yu, et al. “Plasma Proteomics of COVID-19–Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics.” JACC: Basic to Translational Science 7, no. 5 (May 1, 2022): 425–41. https://doi.org/10.1016/j.jacbts.2022.01.013.
Roh JD, Kitchen RR, Guseh JS, McNeill JN, Aid M, Martinot AJ, et al. Plasma Proteomics of COVID-19–Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics. JACC: Basic to Translational Science. 2022 May 1;7(5):425–41.
Roh, J. D., et al. “Plasma Proteomics of COVID-19–Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics.” JACC: Basic to Translational Science, vol. 7, no. 5, May 2022, pp. 425–41. Scopus, doi:10.1016/j.jacbts.2022.01.013.
Roh JD, Kitchen RR, Guseh JS, McNeill JN, Aid M, Martinot AJ, Yu A, Platt C, Rhee J, Weber B, Trager LE, Hastings MH, Ducat S, Xia P, Castro C, Singh A, Atlason B, Churchill TW, Di Carli MF, Ellinor PT, Barouch DH, Ho JE, Rosenzweig A. Plasma Proteomics of COVID-19–Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics. JACC: Basic to Translational Science. 2022 May 1;7(5):425–441.
Journal cover image

Published In

JACC: Basic to Translational Science

DOI

ISSN

2452-302X

Publication Date

May 1, 2022

Volume

7

Issue

5

Start / End Page

425 / 441

Related Subject Headings

  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology