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Changes in activity impairment and work productivity after treatment for vitreous hemorrhage due to proliferative diabetic retinopathy: Secondary outcomes from a randomized controlled trial (DRCR Retina Network Protocol AB).

Publication ,  Journal Article
Beaulieu, WT; Maguire, MG; Antoszyk, AN; DRCR Retina Network,
Published in: PLoS One
2023

BACKGROUND: Vitreous hemorrhage from proliferative diabetic retinopathy can cause severe vision loss. DRCR Retina Network Protocol AB was a randomized clinical trial comparing intravitreal aflibercept versus vitrectomy with panretinal photocoagulation and found no difference in the average rate of visual recovery over 104 weeks. Herein, we describe patient-reported outcome measures from Protocol AB. METHODS: Secondary analysis of a multicenter (39 sites) randomized clinical trial. The Work Productivity and Activity Impairment Questionnaire was administered at 4, 12, 24, 36, 52, 68, 84, and 104 weeks. Main outcomes were mean change in activity impairment and work productivity loss over 24 and 104 weeks (area under the curve). RESULTS: Mean (SD) activity impairment at baseline was 58% (27%) in the aflibercept group (N = 99) and 56% (30%) in the vitrectomy group (N = 105). The mean reduction in activity impairment from baseline over 24 weeks was 21% (25%) in the aflibercept group and 27% (31%) in the vitrectomy group (adjusted difference = -6.8% [95% CI, -12.7% to -0.9%], P = .02); over 104 weeks, the adjusted mean difference was -3.1% (95% CI, -9.2% to 3.0%, P = .31). Mean work productivity loss at baseline was 51% (28%) in the aflibercept group (N = 44) and 58% (30%) in the vitrectomy group (N = 43). The mean reduction in work productivity loss from baseline over 24 weeks (area under the curve) was 19% (23%) in the aflibercept group and 31% (24%) in the vitrectomy group (adjusted difference = -8.3% [95% CI, -16.8% to 0.2%], P = .06); over 104 weeks, the adjusted mean difference was -9.1% (95% CI, -18.4% to 0.2%, P = .05). CONCLUSIONS: Participants with vitreous hemorrhage from proliferative diabetic retinopathy had less activity impairment over 24 weeks when treated initially with vitrectomy and panretinal photocoagulation versus intravitreal aflibercept. The trend was similar for work productivity but not statistically significant. By 104 weeks, the improvements were similar in the two treatment groups. TRIAL REGISTRATION: ClinicalTrials.gov NCT02858076.

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2023

Volume

18

Issue

11

Start / End Page

e0293543

Location

United States

Related Subject Headings

  • Vitreous Hemorrhage
  • Visual Acuity
  • Retina
  • Intravitreal Injections
  • Humans
  • General Science & Technology
  • Diabetic Retinopathy
  • Diabetes Mellitus
  • Angiogenesis Inhibitors
 

Citation

APA
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Beaulieu, W. T., Maguire, M. G., Antoszyk, A. N., & DRCR Retina Network, . (2023). Changes in activity impairment and work productivity after treatment for vitreous hemorrhage due to proliferative diabetic retinopathy: Secondary outcomes from a randomized controlled trial (DRCR Retina Network Protocol AB). PLoS One, 18(11), e0293543. https://doi.org/10.1371/journal.pone.0293543
Beaulieu, Wesley T., Maureen G. Maguire, Andrew N. Antoszyk, and Andrew N. DRCR Retina Network. “Changes in activity impairment and work productivity after treatment for vitreous hemorrhage due to proliferative diabetic retinopathy: Secondary outcomes from a randomized controlled trial (DRCR Retina Network Protocol AB).PLoS One 18, no. 11 (2023): e0293543. https://doi.org/10.1371/journal.pone.0293543.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2023

Volume

18

Issue

11

Start / End Page

e0293543

Location

United States

Related Subject Headings

  • Vitreous Hemorrhage
  • Visual Acuity
  • Retina
  • Intravitreal Injections
  • Humans
  • General Science & Technology
  • Diabetic Retinopathy
  • Diabetes Mellitus
  • Angiogenesis Inhibitors