Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy.
Cancer continues to be a major health concern globally, although the advent of targeted therapy has revolutionized treatment options. Aurora Kinase B is a serine-threonine kinase that has been explored as an oncology therapeutic target for more than two decades. Aurora Kinase B inhibitors show promising biological results in in-vitro and in-vivo experiments. However, there are no inhibitors approved yet for clinical use, primarily because of the side effects associated with Aurora B inhibitors. Several studies demonstrate that Aurora B inhibitors show excellent synergy with various chemotherapeutic agents, radiation therapy, and targeted therapies. This makes it an excellent choice as an adjuvant therapy to first-line therapies, which greatly improves the therapeutic window and side effect profile. Recent studies indicate the role of Aurora B in some deadly cancers with limited therapeutic options, like triple-negative breast cancer and glioblastoma. Herein, we review the latest developments in Aurora Kinase B targeted research, with emphasis on its potential as an adjuvant therapy and its role in some of the most difficult-to-treat cancers.
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Related Subject Headings
- Protein Serine-Threonine Kinases
- Protein Kinase Inhibitors
- Neoplasms
- Medicinal & Biomolecular Chemistry
- Humans
- Cell Line, Tumor
- Aurora Kinase B
- Aurora Kinase A
- Antineoplastic Agents
- 3404 Medicinal and biomolecular chemistry
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Protein Serine-Threonine Kinases
- Protein Kinase Inhibitors
- Neoplasms
- Medicinal & Biomolecular Chemistry
- Humans
- Cell Line, Tumor
- Aurora Kinase B
- Aurora Kinase A
- Antineoplastic Agents
- 3404 Medicinal and biomolecular chemistry