Clinical analysis of 139 cases of infantile cow's milk protein allergy
Objective To analyze the clinical characteristics and therapeutic effect of cow's milk protein allergy (CMPA) in infants, in order to improve the clinical diagnosis and treatment of CMPA. Methods A total of 139 infants with CMPA in Tangdu Hospital of Air Force Military Medical University were enrolled in this study from January 2018 to December 2019, and their clinical manifestations and therapeutic effects were analyzed. Results 1) Among these 139 cases of CMPA, there were 98 cases with gastrointestinal tract symptoms, 80 cases with skin symptoms, 21 cases with respiratory symptoms, 10 cases with anemia and 24 cases with restlessness. 2) The total effective rates of treatment for 4 weeks and 8 weeks in 138 CMPA cases were 68. 3% and 81. 3%, respectively. 31 cases were treated with probiotics for 8 weeks, the total effective rate of probiotic group and control group was 90. 3% and 78. 3% respectively, the difference was not significant (χ2= 2. 219, P = 0. 136). However, infants in probiotic group had showed significant improvement in symptoms of vomiting, antifeedant, bloody stool and eczema(P<0. 05), while significant improvements were only seen in vomiting and eczema in control group (P<0. 05). Conclusions The clinical manifestations of CMPA are diverse. Clinical diagnosis and treatment should be based on the condition of children. Besides, extensively hydrolysed formula(eHF) remains the recommended and preferred therapeutic choice, and amino acid formula(AAF) is reserved for the severe cases. The supplementation of probiotics during treatment may be helpful for elimination of the symptoms, and further studies are warranted.
