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Risk stratification utilizing sequential organ failure assessment (SOFA) score, antithrombin activity, and demographic data in sepsis-associated disseminated intravascular coagulation (DIC).

Publication ,  Journal Article
Iba, T; Maier, CL; Tanigawa, T; Levy, JH
Published in: Sci Rep
December 15, 2023

Disseminated intravascular coagulation (DIC) is a frequent complication in patients with sepsis and is associated with increased mortality. Anticoagulant therapy may be appropriate for certain patients with DIC, particularly those with increased disease severity and deficiency in the physiologic anticoagulant antithrombin. We retrospectively analyzed post-marketing survey data from 1562 patients with sepsis-associated DIC and antithrombin activity of 70% or less. All the patients were treated with antithrombin concentrates. Baseline sequential organ failure assessment (SOFA) score, DIC score, and antithrombin activity were assessed. Cox multivariate regression analysis, Kaplan-Meier curve analysis, and receiver operating characteristic (ROC) curve analysis were performed to evaluate the performance of variables used to assess mortality. Furthermore, a decision tree was constructed to classify the risk of 28-day mortality. COX multivariate regression analysis demonstrated a significant association of age, sex, baseline SOFA score, baseline antithrombin activity, and the presence of pneumonia or skin/soft tissue infection with increased mortality. The area under the curve of SOFA score or antithrombin activity for mortality was 0.700 and 0.614, respectively. Kaplan-Meier analysis demonstrated that mortality was significantly higher in patients with SOFA score ≥ 12 and antithrombin activity < 47%. The decision tree analysis accurately classified the risk of death into high (> 40%), medium (40%-20%), and low (< 20%) categories in 86.1% of the cohort. Twenty eight-day mortality can be strongly predicted using baseline SOFA score, antithrombin activity, infection site, age, and sex as variables in the clinical decision tree for patients with sepsis-associated disseminated intravascular coagulation (DIC).

Duke Scholars

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

December 15, 2023

Volume

13

Issue

1

Start / End Page

22502

Location

England

Related Subject Headings

  • Sepsis
  • Risk Assessment
  • Retrospective Studies
  • Organ Dysfunction Scores
  • Humans
  • Disseminated Intravascular Coagulation
  • Demography
  • Antithrombins
  • Antithrombin III
  • Anticoagulants
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Iba, Toshiaki, Cheryl L. Maier, Tomoki Tanigawa, and Jerrold H. Levy. “Risk stratification utilizing sequential organ failure assessment (SOFA) score, antithrombin activity, and demographic data in sepsis-associated disseminated intravascular coagulation (DIC).Sci Rep 13, no. 1 (December 15, 2023): 22502. https://doi.org/10.1038/s41598-023-49855-y.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

December 15, 2023

Volume

13

Issue

1

Start / End Page

22502

Location

England

Related Subject Headings

  • Sepsis
  • Risk Assessment
  • Retrospective Studies
  • Organ Dysfunction Scores
  • Humans
  • Disseminated Intravascular Coagulation
  • Demography
  • Antithrombins
  • Antithrombin III
  • Anticoagulants