A Panel of Slow-Channel Syndrome Mice Reveals a Unique Locomotor Behavioral Signature.
Publication
, Journal Article
Grajales-Reyes, JG; García-González, A; María-Ríos, JC; Grajales-Reyes, GE; Delgado-Vélez, M; Báez-Pagán, CA; Quesada, O; Gómez, CM ...
Published in: Journal of neuromuscular diseases
January 2017
Muscle nicotinic acetylcholine receptor (nAChR) mutations can lead to altered channel kinetics and neuromuscular junction degeneration, a neurodegenerative disorder collectively known as slow-channel syndrome (SCS). A multivariate analysis using running wheels was used to generate activity profiles for a variety of SCS models, uncovering unique locomotor patterns for the different nAChR mutants. Particularly, the αL251T and ɛL269F mutations exhibit decreased event distance, duration, and velocity over a period of 24 hours. Our approach suggests a robust relationship between the pathophysiology of SCS and locomotor activity.
Duke Scholars
Published In
Journal of neuromuscular diseases
DOI
EISSN
2214-3602
ISSN
2214-3599
Publication Date
January 2017
Volume
4
Issue
4
Start / End Page
341 / 347
Related Subject Headings
- Volition
- Syndrome
- Species Specificity
- Receptors, Nicotinic
- Phenotype
- Mutation
- Multivariate Analysis
- Movement Disorders
- Mice, Transgenic
- Mice, Inbred C57BL
Citation
APA
Chicago
ICMJE
MLA
NLM
Grajales-Reyes, J. G., García-González, A., María-Ríos, J. C., Grajales-Reyes, G. E., Delgado-Vélez, M., Báez-Pagán, C. A., … Lasalde-Dominicci, J. A. (2017). A Panel of Slow-Channel Syndrome Mice Reveals a Unique Locomotor Behavioral Signature. Journal of Neuromuscular Diseases, 4(4), 341–347. https://doi.org/10.3233/jnd-170226
Grajales-Reyes, José G., Aurian García-González, José C. María-Ríos, Gary E. Grajales-Reyes, Manuel Delgado-Vélez, Carlos A. Báez-Pagán, Orestes Quesada, Christopher M. Gómez, and José A. Lasalde-Dominicci. “A Panel of Slow-Channel Syndrome Mice Reveals a Unique Locomotor Behavioral Signature.” Journal of Neuromuscular Diseases 4, no. 4 (January 2017): 341–47. https://doi.org/10.3233/jnd-170226.
Grajales-Reyes JG, García-González A, María-Ríos JC, Grajales-Reyes GE, Delgado-Vélez M, Báez-Pagán CA, et al. A Panel of Slow-Channel Syndrome Mice Reveals a Unique Locomotor Behavioral Signature. Journal of neuromuscular diseases. 2017 Jan;4(4):341–7.
Grajales-Reyes, José G., et al. “A Panel of Slow-Channel Syndrome Mice Reveals a Unique Locomotor Behavioral Signature.” Journal of Neuromuscular Diseases, vol. 4, no. 4, Jan. 2017, pp. 341–47. Epmc, doi:10.3233/jnd-170226.
Grajales-Reyes JG, García-González A, María-Ríos JC, Grajales-Reyes GE, Delgado-Vélez M, Báez-Pagán CA, Quesada O, Gómez CM, Lasalde-Dominicci JA. A Panel of Slow-Channel Syndrome Mice Reveals a Unique Locomotor Behavioral Signature. Journal of neuromuscular diseases. 2017 Jan;4(4):341–347.
Published In
Journal of neuromuscular diseases
DOI
EISSN
2214-3602
ISSN
2214-3599
Publication Date
January 2017
Volume
4
Issue
4
Start / End Page
341 / 347
Related Subject Headings
- Volition
- Syndrome
- Species Specificity
- Receptors, Nicotinic
- Phenotype
- Mutation
- Multivariate Analysis
- Movement Disorders
- Mice, Transgenic
- Mice, Inbred C57BL