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Painful Foot Lesions: A Case Report.

Publication ,  Journal Article
Lockard, TJ; Swali, RN; Javid Whitley, M
Published in: Cureus
January 2023

Hand-foot skin reaction (HFSR) is a documented cutaneous adverse reaction to tyrosine kinase inhibitor (TKI) chemotherapy. Cutaneous toxicities such as HFSR can be debilitating and may result in serious complications; however, continued chemotherapy is desirable to optimize the patient's odds of survival and tumor remission. We present a case of a 66-year-old male, with a history of metastatic renal clear cell carcinoma, who was diagnosed with grade 3 HFSR triggered by axitinib, a tyrosine kinase inhibitor. Our patient was able to expeditiously resume chemotherapy after temporary cessation of axitinib with concurrent application of topical steroids and keratolytics. Expedient return to life-prolonging chemotherapy is of great importance for patients with advanced malignancies; therefore, accurate diagnosis and prompt identification of the offending medication are critical to the management of this entity. We aim to increase the awareness of tyrosine kinase inhibitor-induced HFSR and review the diagnosis and current guidelines for management.

Duke Scholars

Published In

Cureus

DOI

ISSN

2168-8184

Publication Date

January 2023

Volume

15

Issue

1

Start / End Page

e33937

Location

United States

Related Subject Headings

  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Lockard, T. J., Swali, R. N., & Javid Whitley, M. (2023). Painful Foot Lesions: A Case Report. Cureus, 15(1), e33937. https://doi.org/10.7759/cureus.33937
Lockard, Trevor J., Ritu N. Swali, and Melodi Javid Whitley. “Painful Foot Lesions: A Case Report.Cureus 15, no. 1 (January 2023): e33937. https://doi.org/10.7759/cureus.33937.
Lockard TJ, Swali RN, Javid Whitley M. Painful Foot Lesions: A Case Report. Cureus. 2023 Jan;15(1):e33937.
Lockard, Trevor J., et al. “Painful Foot Lesions: A Case Report.Cureus, vol. 15, no. 1, Jan. 2023, p. e33937. Pubmed, doi:10.7759/cureus.33937.
Lockard TJ, Swali RN, Javid Whitley M. Painful Foot Lesions: A Case Report. Cureus. 2023 Jan;15(1):e33937.

Published In

Cureus

DOI

ISSN

2168-8184

Publication Date

January 2023

Volume

15

Issue

1

Start / End Page

e33937

Location

United States

Related Subject Headings

  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences