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Macrophages in Nonalcoholic Steatohepatitis: Friend or Foe?

Publication ,  Journal Article
Grunhut, J; Wang, W; Aykut, B; Gakhal, I; Torres-Hernandez, A; Miller, G
Published in: EMJ Hepatology
May 31, 2018
Published version (DOI) Open Access Copy (Duke) Publisher Link

Nonalcoholic steatohepatitis (NASH) is a subtype of nonalcoholic fatty liver disease that is characterised by steatosis, chronic inflammation, and hepatocellular injury with or without fibrosis. The role and activation of macrophages in the pathogenesis of NASH is complex and is being studied for possible therapeutic options to help the millions of people diagnosed with the disease. The purpose of this review is to discuss the pathogenesis of NASH through the activation and role of Kupffer cells and other macrophages in causing inflammation and progression of NASH. Furthermore, this review aims to outline some of the current therapeutic options targeting the pathogenesis of NASH.

Duke Scholars

Berk Aykut
Author Berk Aykut  

Published In

EMJ Hepatology

DOI

10.33590/emjhepatol/10312252

EISSN

2053-4221

Publication Date

May 31, 2018

Start / End Page

100 / 109

Publisher

European Medical Group
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Grunhut, J., Wang, W., Aykut, B., Gakhal, I., Torres-Hernandez, A., & Miller, G. (2018). Macrophages in Nonalcoholic Steatohepatitis: Friend or Foe? EMJ Hepatology, 100–109. https://doi.org/10.33590/emjhepatol/10312252
Grunhut, Joel, Wei Wang, Berk Aykut, Inderdeep Gakhal, Alejandro Torres-Hernandez, and George Miller. “Macrophages in Nonalcoholic Steatohepatitis: Friend or Foe?” EMJ Hepatology, May 31, 2018, 100–109. https://doi.org/10.33590/emjhepatol/10312252.
Grunhut J, Wang W, Aykut B, Gakhal I, Torres-Hernandez A, Miller G. Macrophages in Nonalcoholic Steatohepatitis: Friend or Foe? EMJ Hepatology. 2018 May 31;100–9.
Grunhut, Joel, et al. “Macrophages in Nonalcoholic Steatohepatitis: Friend or Foe?” EMJ Hepatology, European Medical Group, May 2018, pp. 100–09. Crossref, doi:10.33590/emjhepatol/10312252.
Grunhut J, Wang W, Aykut B, Gakhal I, Torres-Hernandez A, Miller G. Macrophages in Nonalcoholic Steatohepatitis: Friend or Foe? EMJ Hepatology. European Medical Group; 2018 May 31;100–109.

Published In

EMJ Hepatology

DOI

10.33590/emjhepatol/10312252

EISSN

2053-4221

Publication Date

May 31, 2018

Start / End Page

100 / 109

Publisher

European Medical Group