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Negative Vaccination Strategies for Promotion of Transplant Tolerance.

Publication ,  Journal Article
Tunbridge, MJ; Luo, X; Thomson, AW
Published in: Transplantation
February 16, 2024

Organ transplantation requires the use of immunosuppressive medications that lack antigen specificity, have many adverse side effects, and fail to induce immunological tolerance to the graft. The safe induction of tolerance to allogeneic tissue without compromising host responses to infection or enhancing the risk of malignant disease is a major goal in transplantation. One promising approach to achieve this goal is based on the concept of "negative vaccination." Vaccination (or actively acquired immunity) involves the presentation of both a foreign antigen and immunostimulatory adjuvant to the immune system to induce antigen-specific immunity. By contrast, negative vaccination, in the context of transplantation, involves the delivery of donor antigen before or after transplantation, together with a "negative adjuvant" to selectively inhibit the alloimmune response. This review will explore established and emerging negative vaccination strategies for promotion of organ or pancreatic islet transplant tolerance. These include donor regulatory myeloid cell infusion, which has progressed to early-phase clinical trials, apoptotic donor cell infusion that has advanced to nonhuman primate models, and novel nanoparticle antigen-delivery systems.

Duke Scholars

Published In

Transplantation

DOI

EISSN

1534-6080

Publication Date

February 16, 2024

Location

United States

Related Subject Headings

  • Surgery
  • 3204 Immunology
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences
 

Citation

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Tunbridge, M. J., Luo, X., & Thomson, A. W. (2024). Negative Vaccination Strategies for Promotion of Transplant Tolerance. Transplantation. https://doi.org/10.1097/TP.0000000000004911
Tunbridge, Matthew J., Xunrong Luo, and Angus W. Thomson. “Negative Vaccination Strategies for Promotion of Transplant Tolerance.Transplantation, February 16, 2024. https://doi.org/10.1097/TP.0000000000004911.
Tunbridge MJ, Luo X, Thomson AW. Negative Vaccination Strategies for Promotion of Transplant Tolerance. Transplantation. 2024 Feb 16;
Tunbridge, Matthew J., et al. “Negative Vaccination Strategies for Promotion of Transplant Tolerance.Transplantation, Feb. 2024. Pubmed, doi:10.1097/TP.0000000000004911.
Tunbridge MJ, Luo X, Thomson AW. Negative Vaccination Strategies for Promotion of Transplant Tolerance. Transplantation. 2024 Feb 16;

Published In

Transplantation

DOI

EISSN

1534-6080

Publication Date

February 16, 2024

Location

United States

Related Subject Headings

  • Surgery
  • 3204 Immunology
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences