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Kidney Disease Modeling with Organoids and Organs-on-Chips.

Publication ,  Journal Article
Musah, S; Bhattacharya, R; Himmelfarb, J
Published in: Annual review of biomedical engineering
February 2024

Kidney disease is a global health crisis affecting more than 850 million people worldwide. In the United States, annual Medicare expenditures for kidney disease and organ failure exceed $81 billion. Efforts to develop targeted therapeutics are limited by a poor understanding of the molecular mechanisms underlying human kidney disease onset and progression. Additionally, 90% of drug candidates fail in human clinical trials, often due to toxicity and efficacy not accurately predicted in animal models. The advent of ex vivo kidney models, such as those engineered from induced pluripotent stem (iPS) cells and organ-on-a-chip (organ-chip) systems have garnered considerable interest owing to their ability to more accurately model tissue development and patient-specific responses and drug toxicity. This review describes recent advances in developing kidney organoids and organ-chips by harnessing iPS cell biology to model human-specific kidney functions and disease states. We also discuss challenges that must be overcome to realize the potential of organoids and organ-chips as dynamic and functional conduits of the human kidney. Achieving these technological advances could revolutionize personalized medicine applications and therapeutic discovery for kidney disease. Expected final online publication date for the Annual Review of Biomedical Engineering, Volume 26 is May 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Published In

Annual review of biomedical engineering

DOI

EISSN

1545-4274

ISSN

1523-9829

Publication Date

February 2024

Related Subject Headings

  • Biomedical Engineering
  • 0903 Biomedical Engineering
 

Citation

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Musah, S., Bhattacharya, R., & Himmelfarb, J. (2024). Kidney Disease Modeling with Organoids and Organs-on-Chips. Annual Review of Biomedical Engineering. https://doi.org/10.1146/annurev-bioeng-072623-044010
Musah, Samira, Rohan Bhattacharya, and Jonathan Himmelfarb. “Kidney Disease Modeling with Organoids and Organs-on-Chips.Annual Review of Biomedical Engineering, February 2024. https://doi.org/10.1146/annurev-bioeng-072623-044010.
Musah S, Bhattacharya R, Himmelfarb J. Kidney Disease Modeling with Organoids and Organs-on-Chips. Annual review of biomedical engineering. 2024 Feb;
Musah, Samira, et al. “Kidney Disease Modeling with Organoids and Organs-on-Chips.Annual Review of Biomedical Engineering, Feb. 2024. Epmc, doi:10.1146/annurev-bioeng-072623-044010.
Musah S, Bhattacharya R, Himmelfarb J. Kidney Disease Modeling with Organoids and Organs-on-Chips. Annual review of biomedical engineering. 2024 Feb;

Published In

Annual review of biomedical engineering

DOI

EISSN

1545-4274

ISSN

1523-9829

Publication Date

February 2024

Related Subject Headings

  • Biomedical Engineering
  • 0903 Biomedical Engineering