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Spatially Segregated Macrophage Populations Predict Distinct Outcomes In Colon Cancer.

Publication ,  Journal Article
Matusiak, M; Hickey, JW; van IJzendoorn, DGP; Lu, G; Kidzinski, L; Zhu, S; Colburg, DRC; Luca, B; Phillips, DJ; Brubaker, SW; Charville, GW ...
Published in: Cancer discovery
March 2024

Tumor-associated macrophages are transcriptionally heterogeneous, but the spatial distribution and cell interactions that shape macrophage tissue roles remain poorly characterized. Here, we spatially resolve five distinct human macrophage populations in normal and malignant human breast and colon tissue and reveal their cellular associations. This spatial map reveals that distinct macrophage populations reside in spatially segregated micro-environmental niches with conserved cellular compositions that are repeated across healthy and diseased tissue. We show that IL4I1+ macrophages phagocytose dying cells in areas with high cell turnover and predict good outcome in colon cancer. In contrast, SPP1+ macrophages are enriched in hypoxic and necrotic tumor regions and portend worse outcome in colon cancer. A subset of FOLR2+ macrophages is embedded in plasma cell niches. NLRP3+ macrophages co-localize with neutrophils and activate an inflammasome in tumors. Our findings indicate that a limited number of unique human macrophage niches function as fundamental building blocks in tissue.

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Published In

Cancer discovery

DOI

EISSN

2159-8290

ISSN

2159-8274

Publication Date

March 2024

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis
 

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Matusiak, M., Hickey, J. W., van IJzendoorn, D. G. P., Lu, G., Kidzinski, L., Zhu, S., … van de Rijn, M. (2024). Spatially Segregated Macrophage Populations Predict Distinct Outcomes In Colon Cancer. Cancer Discovery. https://doi.org/10.1158/2159-8290.cd-23-1300
Matusiak, Magdalena, John W. Hickey, David G. P. van IJzendoorn, Guolan Lu, Lukasz Kidzinski, Shirley Zhu, Deana R. C. Colburg, et al. “Spatially Segregated Macrophage Populations Predict Distinct Outcomes In Colon Cancer.Cancer Discovery, March 2024. https://doi.org/10.1158/2159-8290.cd-23-1300.
Matusiak M, Hickey JW, van IJzendoorn DGP, Lu G, Kidzinski L, Zhu S, et al. Spatially Segregated Macrophage Populations Predict Distinct Outcomes In Colon Cancer. Cancer discovery. 2024 Mar;
Matusiak, Magdalena, et al. “Spatially Segregated Macrophage Populations Predict Distinct Outcomes In Colon Cancer.Cancer Discovery, Mar. 2024. Epmc, doi:10.1158/2159-8290.cd-23-1300.
Matusiak M, Hickey JW, van IJzendoorn DGP, Lu G, Kidzinski L, Zhu S, Colburg DRC, Luca B, Phillips DJ, Brubaker SW, Charville GW, Shen J, Loh KM, Okwan-Duodu DK, Nolan GP, Newman AM, West RB, van de Rijn M. Spatially Segregated Macrophage Populations Predict Distinct Outcomes In Colon Cancer. Cancer discovery. 2024 Mar;

Published In

Cancer discovery

DOI

EISSN

2159-8290

ISSN

2159-8274

Publication Date

March 2024

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis