Skip to main content

Expectations of preventative benefits and risk behaviors in a randomized trial evaluating oral HIV preexposure prophylaxis candidates.

Publication ,  Journal Article
Sugarman, J; Weir, BW; Dun, C; Gulick, RM; Wilkin, TJ; Mayer, KH; McCauley, M; Weinfurt, KP
Published in: AIDS Care
April 12, 2024

When participants enrolled in an HIV prevention trial hold a preventive misconception (PM) - expectations that experimental interventions will confer protection from HIV infection - they may engage in behaviors that increase their risk of acquiring HIV. This can raise ethical concerns about whether those enrolled in the trial understand the nature of participation and their safety. Consequently, we systematically evaluated the prevalence of PM and its association with risk behaviors in a trial examining three candidate regimens for oral HIV pre-exposure prophylaxis in which all participants received at least one antiretroviral agent. Overall, trial participants exhibited relatively high preventive expectations that may be associated with an increase in risk behaviors among men who have sex with men. In addition, we identified substantial site variability in PM that necessitates future research to uncover its source. This will allow appropriate measures to be taken to mitigate PM and help ensure that participants have an accurate understanding of the potential risks and benefits of trial participation throughout the course of a trial.

Duke Scholars

Published In

AIDS Care

DOI

EISSN

1360-0451

Publication Date

April 12, 2024

Start / End Page

1 / 7

Location

England

Related Subject Headings

  • Public Health
  • 5203 Clinical and health psychology
  • 4410 Sociology
  • 4206 Public health
  • 1701 Psychology
  • 1117 Public Health and Health Services
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sugarman, J., Weir, B. W., Dun, C., Gulick, R. M., Wilkin, T. J., Mayer, K. H., … Weinfurt, K. P. (2024). Expectations of preventative benefits and risk behaviors in a randomized trial evaluating oral HIV preexposure prophylaxis candidates. AIDS Care, 1–7. https://doi.org/10.1080/09540121.2024.2332446
Sugarman, Jeremy, Brian W. Weir, Chen Dun, Roy M. Gulick, Timothy J. Wilkin, Kenneth H. Mayer, Marybeth McCauley, and Kevin P. Weinfurt. “Expectations of preventative benefits and risk behaviors in a randomized trial evaluating oral HIV preexposure prophylaxis candidates.AIDS Care, April 12, 2024, 1–7. https://doi.org/10.1080/09540121.2024.2332446.
Sugarman J, Weir BW, Dun C, Gulick RM, Wilkin TJ, Mayer KH, et al. Expectations of preventative benefits and risk behaviors in a randomized trial evaluating oral HIV preexposure prophylaxis candidates. AIDS Care. 2024 Apr 12;1–7.
Sugarman, Jeremy, et al. “Expectations of preventative benefits and risk behaviors in a randomized trial evaluating oral HIV preexposure prophylaxis candidates.AIDS Care, Apr. 2024, pp. 1–7. Pubmed, doi:10.1080/09540121.2024.2332446.
Sugarman J, Weir BW, Dun C, Gulick RM, Wilkin TJ, Mayer KH, McCauley M, Weinfurt KP. Expectations of preventative benefits and risk behaviors in a randomized trial evaluating oral HIV preexposure prophylaxis candidates. AIDS Care. 2024 Apr 12;1–7.

Published In

AIDS Care

DOI

EISSN

1360-0451

Publication Date

April 12, 2024

Start / End Page

1 / 7

Location

England

Related Subject Headings

  • Public Health
  • 5203 Clinical and health psychology
  • 4410 Sociology
  • 4206 Public health
  • 1701 Psychology
  • 1117 Public Health and Health Services