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Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.

Publication ,  Journal Article
Strom, NI; Gerring, ZF; Galimberti, M; Yu, D; Halvorsen, MW; Abdellaoui, A; Rodriguez-Fontenla, C; Sealock, JM; Bigdeli, T; Coleman, JR; Bey, K ...
Published in: medRxiv
April 8, 2025

Obsessive-compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based approaches identified 249 potential effector genes for OCD, with 25 of these classified as the most likely causal candidates, including WDR6, DALRD3, CTNND1 and multiple genes in the MHC region. We estimated that ~11,500 genetic variants explained 90% of OCD genetic heritability. OCD genetic risk was associated with excitatory neurons in the hippocampus and cortex, along with D1- and D2-type dopamine receptor-containing medium spiny neurons. OCD genetic risk was shared with 65 of 112 additional phenotypes, including all of the psychiatric disorders we examined. In particular, OCD shared genetic risk with anxiety, depression, anorexia nervosa, and Tourette syndrome, and was negatively associated with inflammatory bowel diseases, educational attainment, and body mass index.

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medRxiv

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Publication Date

April 8, 2025

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United States
 

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Strom, N. I., Gerring, Z. F., Galimberti, M., Yu, D., Halvorsen, M. W., Abdellaoui, A., … Mattheisen, M. (2025). Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder. MedRxiv. https://doi.org/10.1101/2024.03.13.24304161
Strom, Nora I., Zachary F. Gerring, Marco Galimberti, Dongmei Yu, Matthew W. Halvorsen, Abdel Abdellaoui, Cristina Rodriguez-Fontenla, et al. “Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.MedRxiv, April 8, 2025. https://doi.org/10.1101/2024.03.13.24304161.
Strom NI, Gerring ZF, Galimberti M, Yu D, Halvorsen MW, Abdellaoui A, et al. Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder. medRxiv. 2025 Apr 8;
Strom, Nora I., et al. “Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.MedRxiv, Apr. 2025. Pubmed, doi:10.1101/2024.03.13.24304161.
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Published In

medRxiv

DOI

Publication Date

April 8, 2025

Location

United States