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Impact of an individualized pain plan to treat sickle cell disease vaso-occlusive episodes in the emergency department.

Publication ,  Journal Article
Siewny, L; King, A; Melvin, CL; Carpenter, CR; Hankins, JS; Colla, JS; Preiss, L; Luo, L; Cox, L; Treadwell, M; Davila, N; Masese, RV ...
Published in: Blood Adv
October 22, 2024

To address acute vaso-occlusive episodes (VOEs), the leading cause of emergency department (ED) visits among individuals with sickle cell disease (SCD), we conducted the clinical study, ALIGN (An Individualized Pain Plan with Patient and Provider Access for Emergency Department care of SCD), across 8 sites. We hypothesized an improvement of 0.5 standard deviations in perceived quality of ED pain treatment of a VOE after implementing individualized pain plans (IPPs) accessible to both patients and providers. Patients with SCD were aged 18 to 45 years, owned a cell phone, and had an ED VOE visit within 90 days prior. Patients completed the perceived quality of care surveys at baseline and within 96 hours after an ED VOE visit. Providers completed surveys regarding comfort managing VOEs at baseline and after managing an enrolled patient. Most of the 153 patients were African American (95.4%), female (64.7%), and had Hb SS/Sβ0 genotype (71.9%). The perceived quality of ED pain treatment was high at both baseline and after implementation of IPPs; our primary outcome hypothesis was not met, because no statistically significant change in the patient-perceived quality of ED treatment occurred. A total of 135 providers completed baseline and follow-up surveys. On a scale of 1 to 7, with 7 being extremely comfortable managing VOEs, 60.5% reported a score ≥6 after IPP implementation vs 57.8% at baseline. Almost all (97.6%) ordered the recommended medication, and 94.7% intended to use IPPs. In this implementation protocol, all sites successfully implemented IPPs. Patients and ED providers both endorsed the use of IPPs. This trial was registered at www.ClinicalTrials.gov as # NCT04584528.

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Published In

Blood Adv

DOI

EISSN

2473-9537

Publication Date

October 22, 2024

Volume

8

Issue

20

Start / End Page

5330 / 5338

Location

United States

Related Subject Headings

  • Young Adult
  • Pain Management
  • Pain
  • Middle Aged
  • Male
  • Humans
  • Female
  • Emergency Service, Hospital
  • Anemia, Sickle Cell
  • Adult
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Siewny, L., King, A., Melvin, C. L., Carpenter, C. R., Hankins, J. S., Colla, J. S., … Tanabe, P. (2024). Impact of an individualized pain plan to treat sickle cell disease vaso-occlusive episodes in the emergency department. Blood Adv, 8(20), 5330–5338. https://doi.org/10.1182/bloodadvances.2023012439
Siewny, Lauren, Allison King, Cathy L. Melvin, Christopher R. Carpenter, Jane S. Hankins, Joseph S. Colla, Liliana Preiss, et al. “Impact of an individualized pain plan to treat sickle cell disease vaso-occlusive episodes in the emergency department.Blood Adv 8, no. 20 (October 22, 2024): 5330–38. https://doi.org/10.1182/bloodadvances.2023012439.
Siewny L, King A, Melvin CL, Carpenter CR, Hankins JS, Colla JS, et al. Impact of an individualized pain plan to treat sickle cell disease vaso-occlusive episodes in the emergency department. Blood Adv. 2024 Oct 22;8(20):5330–8.
Siewny, Lauren, et al. “Impact of an individualized pain plan to treat sickle cell disease vaso-occlusive episodes in the emergency department.Blood Adv, vol. 8, no. 20, Oct. 2024, pp. 5330–38. Pubmed, doi:10.1182/bloodadvances.2023012439.
Siewny L, King A, Melvin CL, Carpenter CR, Hankins JS, Colla JS, Preiss L, Luo L, Cox L, Treadwell M, Davila N, Masese RV, McCuskee S, Gollan SS, Tanabe P. Impact of an individualized pain plan to treat sickle cell disease vaso-occlusive episodes in the emergency department. Blood Adv. 2024 Oct 22;8(20):5330–5338.

Published In

Blood Adv

DOI

EISSN

2473-9537

Publication Date

October 22, 2024

Volume

8

Issue

20

Start / End Page

5330 / 5338

Location

United States

Related Subject Headings

  • Young Adult
  • Pain Management
  • Pain
  • Middle Aged
  • Male
  • Humans
  • Female
  • Emergency Service, Hospital
  • Anemia, Sickle Cell
  • Adult