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Astroviruses in terrestrial Malagasy mammals.

Publication ,  Journal Article
Carcauzon, V; Herrera, JP; Kaufman, K; Baudino, F; Wickenkamp, N; Randriamoria, TM; Soarimalala, V; Goodman, SM; Nunn, CL; Lebarbenchon, C; Tortosa, P
Published in: PLoS neglected tropical diseases
June 2024

Small terrestrial mammals are major hosts of infectious agents responsible for zoonotic diseases. Astroviruses (AstVs)-the cause of non-bacterial gastroenteritis mainly affecting young children-have been detected in a wide array of mammalian and avian host species. However, understanding the factors that influence AstV infection within and across hosts is limited. Here, we investigated the impact of land use changes on AstVs in terrestrial small mammals in rural northeastern Madagascar. We sampled 515 small mammals, representing seven endemic and four introduced species. Twenty-two positive samples were identified, all but one of which were found in the introduced species Mus musculus and Rattus rattus (family Muridae), with a positivity rate of 7.7% (6/78) and 5.6% (15/266), respectively. The non-introduced rodent case was from an endemic shrew-tenrec (family Tenrecidae). We found the highest positivity rate of AstVs infection in brushy regrowth (17.5%, 7/40) as compared to flooded rice fields (4.60%, 8/174), secondary forest (4.1%, 3/74), agroforest (3.6%, 1/28), village (2.61%, 3/115), and semi-intact forest (0%, 0/84). A phylogenetic analysis revealed an association between AstVs and their rodent host species. None of the viruses were phylogenetically related to AstVs previously described in Malagasy bats. This study supports AstV circulation in synanthropic animals in agricultural habitats of Madagascar and highlights the need to assess the spillover risk to human populations in rural areas.

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Published In

PLoS neglected tropical diseases

DOI

EISSN

1935-2735

ISSN

1935-2727

Publication Date

June 2024

Volume

18

Issue

6

Start / End Page

e0012263

Related Subject Headings

  • Zoonoses
  • Tropical Medicine
  • Rats
  • Phylogeny
  • Mice
  • Mammals
  • Madagascar
  • Astroviridae Infections
  • Astroviridae
  • Animals
 

Citation

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Carcauzon, V., Herrera, J. P., Kaufman, K., Baudino, F., Wickenkamp, N., Randriamoria, T. M., … Tortosa, P. (2024). Astroviruses in terrestrial Malagasy mammals. PLoS Neglected Tropical Diseases, 18(6), e0012263. https://doi.org/10.1371/journal.pntd.0012263
Carcauzon, Victoria, James P. Herrera, Kayla Kaufman, Fiona Baudino, Natalie Wickenkamp, Toky M. Randriamoria, Voahangy Soarimalala, et al. “Astroviruses in terrestrial Malagasy mammals.PLoS Neglected Tropical Diseases 18, no. 6 (June 2024): e0012263. https://doi.org/10.1371/journal.pntd.0012263.
Carcauzon V, Herrera JP, Kaufman K, Baudino F, Wickenkamp N, Randriamoria TM, et al. Astroviruses in terrestrial Malagasy mammals. PLoS neglected tropical diseases. 2024 Jun;18(6):e0012263.
Carcauzon, Victoria, et al. “Astroviruses in terrestrial Malagasy mammals.PLoS Neglected Tropical Diseases, vol. 18, no. 6, June 2024, p. e0012263. Epmc, doi:10.1371/journal.pntd.0012263.
Carcauzon V, Herrera JP, Kaufman K, Baudino F, Wickenkamp N, Randriamoria TM, Soarimalala V, Goodman SM, Nunn CL, Lebarbenchon C, Tortosa P. Astroviruses in terrestrial Malagasy mammals. PLoS neglected tropical diseases. 2024 Jun;18(6):e0012263.

Published In

PLoS neglected tropical diseases

DOI

EISSN

1935-2735

ISSN

1935-2727

Publication Date

June 2024

Volume

18

Issue

6

Start / End Page

e0012263

Related Subject Headings

  • Zoonoses
  • Tropical Medicine
  • Rats
  • Phylogeny
  • Mice
  • Mammals
  • Madagascar
  • Astroviridae Infections
  • Astroviridae
  • Animals