Possible Binding of Piperine in Mycobacterium tuberculosis RNA Polymerase and Rifampin Synergism.
Publication
, Journal Article
Murase, LS; Perez de Souza, JV; Meneguello, JE; Seixas, FAV; Hegeto, LA; Scodro, RBDL; Siqueira, VLD; Caleffi Ferracioli, KR; Cardoso, RF
Published in: Antimicrob Agents Chemother
November 2019
The activity of rifampin (RIF) and piperine was evaluated at the relative transcript levels of 12 efflux pumps (EPs), and an additional mechanism was proposed to be behind the synergic interactions of piperine plus RIF in Mycobacterium tuberculosis AutoDock v4.2.3 and Molegro v6 programs were used to evaluate PIP binding in M. tuberculosis RNA polymerase (RNAP). A hypothesis has been raised that piperine interferes in M. tuberculosis growth through RNAP inhibition, differently from what was previously endorsed for EP inhibition only.
Duke Scholars
Published In
Antimicrob Agents Chemother
DOI
EISSN
1098-6596
Publication Date
November 2019
Volume
63
Issue
11
Location
United States
Related Subject Headings
- Rifampin
- Reverse Transcriptase Polymerase Chain Reaction
- Polyunsaturated Alkamides
- Piperidines
- Mycobacterium tuberculosis
- Molecular Docking Simulation
- Microbiology
- Drug Therapy, Combination
- Drug Synergism
- DNA-Directed RNA Polymerases
Citation
APA
Chicago
ICMJE
MLA
NLM
Murase, L. S., Perez de Souza, J. V., Meneguello, J. E., Seixas, F. A. V., Hegeto, L. A., Scodro, R. B. D. L., … Cardoso, R. F. (2019). Possible Binding of Piperine in Mycobacterium tuberculosis RNA Polymerase and Rifampin Synergism. Antimicrob Agents Chemother, 63(11). https://doi.org/10.1128/AAC.02520-18
Murase, Letícia Sayuri, João Vítor Perez de Souza, Jean Eduardo Meneguello, Flavio Augusto Vicente Seixas, Laíse Adriane Hegeto, Regiane Bertin de Lima Scodro, Vera Lucia Dias Siqueira, Katiany Rizzieri Caleffi Ferracioli, and Rosilene Fressatti Cardoso. “Possible Binding of Piperine in Mycobacterium tuberculosis RNA Polymerase and Rifampin Synergism.” Antimicrob Agents Chemother 63, no. 11 (November 2019). https://doi.org/10.1128/AAC.02520-18.
Murase LS, Perez de Souza JV, Meneguello JE, Seixas FAV, Hegeto LA, Scodro RBDL, et al. Possible Binding of Piperine in Mycobacterium tuberculosis RNA Polymerase and Rifampin Synergism. Antimicrob Agents Chemother. 2019 Nov;63(11).
Murase, Letícia Sayuri, et al. “Possible Binding of Piperine in Mycobacterium tuberculosis RNA Polymerase and Rifampin Synergism.” Antimicrob Agents Chemother, vol. 63, no. 11, Nov. 2019. Pubmed, doi:10.1128/AAC.02520-18.
Murase LS, Perez de Souza JV, Meneguello JE, Seixas FAV, Hegeto LA, Scodro RBDL, Siqueira VLD, Caleffi Ferracioli KR, Cardoso RF. Possible Binding of Piperine in Mycobacterium tuberculosis RNA Polymerase and Rifampin Synergism. Antimicrob Agents Chemother. 2019 Nov;63(11).
Published In
Antimicrob Agents Chemother
DOI
EISSN
1098-6596
Publication Date
November 2019
Volume
63
Issue
11
Location
United States
Related Subject Headings
- Rifampin
- Reverse Transcriptase Polymerase Chain Reaction
- Polyunsaturated Alkamides
- Piperidines
- Mycobacterium tuberculosis
- Molecular Docking Simulation
- Microbiology
- Drug Therapy, Combination
- Drug Synergism
- DNA-Directed RNA Polymerases