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Real-world treatment patterns of patients with major depressive disorder treated with Auvelity in the United States.

Publication ,  Journal Article
Muzyk, A; Syed, FZ; Zhou, H; Cong, J; Tabuteau, H; Zhao, Y
Published in: J Med Econ
2024

AIMS: Major depressive disorder (MDD) is a prevalent, chronic disorder. Auvelity (dextromethorphan-bupropion) is a novel, oral N-methyl-D-aspartate (NMDA) receptor antagonist and sigma-1 receptor agonist approved (August 2022) by the FDA for treating MDD in adults. This is the first analysis on real-world Auvelity usage in the United States. METHODS: Adult patients initiating Auvelity in the Symphony IDV databases by September 2023 were identified (index date: the first Auvelity claim). Patients had continuous eligibility over the 12-month pre-index period and ≥1 MDD diagnosis (ICD-10-CM codes: F32.*, F33.*) over the 5-year pre-index period. Demographic and clinical characteristics, comorbidities, prior MDD-related medications, and Auvelity initiation status were assessed. RESULTS: This analysis included 22,288 patients with MDD treated with Auvelity (mean age 45.1 years; 68.1% women); 40.0% lived in the South and 58.5% had commercial insurance. Comorbidities included mental health disorders (53.5%; 47.6% had anxiety disorders). Overall, 83.7% of the patients had received treatment with selective serotonin reuptake inhibitors (SSRIs; 54.9%), the norepinephrine-dopamine reuptake inhibitor (NDRI [bupropion]; 40.4%), and/or serotonin-norepinephrine reuptake inhibitors (SNRIs; 35.9%) over the 12-month pre-index period. The last MDD-related treatment prior to Auvelity comprised SSRI (22.4%), SNRI (13.2%), and NDRI (12.8%) monotherapies; 294 (1.3%) patients received esketamine. In total, 6,418 (28.8%) patients initiated Auvelity as monotherapy vs 15,870 (71.2%) as an add-on; Auvelity was most frequently added to an SSRI alone (10.7%) or SNRI alone (6.5%). A total of 2,254 (10.1%) patients initiated Auvelity without prior treatment in the 12-month pre-index period. LIMITATIONS: Incomplete data due to reporting; diagnoses captured subject to coding error; and limited generalizability to other populations. CONCLUSIONS: Using a large demographically distributed claims database, 22,288 patients with MDD initiated Auvelity within a year of its approval; 10.1% were treatment-naïve and 28.8% initiated Auvelity as monotherapy. Most patients had mental health-related comorbidities and attempted various MDD-related treatments prior to Auvelity.

Duke Scholars

Published In

J Med Econ

DOI

EISSN

1941-837X

Publication Date

2024

Volume

27

Issue

1

Start / End Page

1003 / 1010

Location

England

Related Subject Headings

  • Young Adult
  • United States
  • Retrospective Studies
  • Middle Aged
  • Male
  • Insurance Claim Review
  • Humans
  • Health Policy & Services
  • Female
  • Drug Combinations
 

Citation

APA
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ICMJE
MLA
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Muzyk, A., Syed, F. Z., Zhou, H., Cong, J., Tabuteau, H., & Zhao, Y. (2024). Real-world treatment patterns of patients with major depressive disorder treated with Auvelity in the United States. J Med Econ, 27(1), 1003–1010. https://doi.org/10.1080/13696998.2024.2382641
Muzyk, Andrew, Fatima Zahara Syed, Huanxue Zhou, Junjun Cong, Herriot Tabuteau, and Yang Zhao. “Real-world treatment patterns of patients with major depressive disorder treated with Auvelity in the United States.J Med Econ 27, no. 1 (2024): 1003–10. https://doi.org/10.1080/13696998.2024.2382641.
Muzyk A, Syed FZ, Zhou H, Cong J, Tabuteau H, Zhao Y. Real-world treatment patterns of patients with major depressive disorder treated with Auvelity in the United States. J Med Econ. 2024;27(1):1003–10.
Muzyk, Andrew, et al. “Real-world treatment patterns of patients with major depressive disorder treated with Auvelity in the United States.J Med Econ, vol. 27, no. 1, 2024, pp. 1003–10. Pubmed, doi:10.1080/13696998.2024.2382641.
Muzyk A, Syed FZ, Zhou H, Cong J, Tabuteau H, Zhao Y. Real-world treatment patterns of patients with major depressive disorder treated with Auvelity in the United States. J Med Econ. 2024;27(1):1003–1010.

Published In

J Med Econ

DOI

EISSN

1941-837X

Publication Date

2024

Volume

27

Issue

1

Start / End Page

1003 / 1010

Location

England

Related Subject Headings

  • Young Adult
  • United States
  • Retrospective Studies
  • Middle Aged
  • Male
  • Insurance Claim Review
  • Humans
  • Health Policy & Services
  • Female
  • Drug Combinations