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Physical Activity and Cognition: Longitudinal findings from the Thinking and Living with Cancer Study.

Publication ,  Journal Article
Artese, AL; Zhou, X; Tometich, DB; Small, BJ; Ahles, TA; Ahn, J; Bethea, TN; Breen, EC; Cohen, HJ; Extermann, M; Graham, D; Isaacs, C ...
Published in: Journal of the National Cancer Institute
August 2024

Physical activity can improve cognition; however, little is known regarding the relationships between longitudinal objectively-measured physical activity, cognition, and inflammation in older breast cancer survivors.Older (≥60 yrs) breast cancer survivors (n = 216) and frequency-matched non-cancer controls (n = 216) were assessed at baseline (pre-systemic therapy for survivors) and annually for up to five years. Assessments included hip-worn ActiGraphs worn for seven days, neuropsychological tests, the Functional Assessment of Cancer Therapy-Cognitive Function Perceived Cognitive Impairment (FACT-Cog PCI) subscale, and circulating levels of C-reactive protein (CRP) and interleukin-6 (IL-6). Data were analyzed using linear mixed-effect, random-effect contemporaneous fluctuation, and multi-level mediation models, considering covariates; p < .05 (two-sided) was considered significant.Survivors had fewer minutes of moderate-to-vigorous physical activity (MVPA) than controls at 36-, 48-, and 60-month time points (p < .03). Fewer survivors met Aerobic Physical Activity Guidelines at 36 months than controls (17.7% vs 33.0%, p = .030). When Guidelines were met (vs not), FACT-Cog PCI scores were 2.1 ± 1.0 (p = .034) points higher. Higher MVPA and meeting Aerobic Guidelines were not related to objective neuropsychological performance. MVPA was inversely associated with CRP and IL-6 (p < .001), but inflammation did not mediate physical activity effects on perceived cognition.Older breast cancer survivors were less physically active than older non-cancer controls, especially farther from baseline. Meeting Aerobic Guidelines was associated with better perceived cognition in survivors. Survivorship care should consider physical activity monitoring and referral to rehabilitation and supervised exercise programs to promote physical activity and improve recovery in older survivors.

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Published In

Journal of the National Cancer Institute

DOI

EISSN

1460-2105

ISSN

0027-8874

Publication Date

August 2024

Start / End Page

djae182

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

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Artese, A. L., Zhou, X., Tometich, D. B., Small, B. J., Ahles, T. A., Ahn, J., … Mandelblatt, J. (2024). Physical Activity and Cognition: Longitudinal findings from the Thinking and Living with Cancer Study. Journal of the National Cancer Institute, djae182. https://doi.org/10.1093/jnci/djae182
Artese, Ashley L., Xingtao Zhou, Danielle B. Tometich, Brent J. Small, Tim A. Ahles, Jaeil Ahn, Traci N. Bethea, et al. “Physical Activity and Cognition: Longitudinal findings from the Thinking and Living with Cancer Study.Journal of the National Cancer Institute, August 2024, djae182. https://doi.org/10.1093/jnci/djae182.
Artese AL, Zhou X, Tometich DB, Small BJ, Ahles TA, Ahn J, et al. Physical Activity and Cognition: Longitudinal findings from the Thinking and Living with Cancer Study. Journal of the National Cancer Institute. 2024 Aug;djae182.
Artese, Ashley L., et al. “Physical Activity and Cognition: Longitudinal findings from the Thinking and Living with Cancer Study.Journal of the National Cancer Institute, Aug. 2024, p. djae182. Epmc, doi:10.1093/jnci/djae182.
Artese AL, Zhou X, Tometich DB, Small BJ, Ahles TA, Ahn J, Bethea TN, Breen EC, Cohen HJ, Extermann M, Graham D, Isaacs C, Jim HSL, McDonald BC, Nakamura ZM, Patel SK, Rentscher KE, Root JC, Saykin AJ, Van Dyk K, Zhai W, Carroll JE, Mandelblatt J. Physical Activity and Cognition: Longitudinal findings from the Thinking and Living with Cancer Study. Journal of the National Cancer Institute. 2024 Aug;djae182.
Journal cover image

Published In

Journal of the National Cancer Institute

DOI

EISSN

1460-2105

ISSN

0027-8874

Publication Date

August 2024

Start / End Page

djae182

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis