Oncogenic Mutant p53 Sensitizes Non-Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress-Dependent Induction of Mitochondrial Apoptosis.
Publication
, Journal Article
Chougoni, KK; Neely, V; Ding, B; Oduah, E; Lam, VT; Hu, B; Koblinski, JE; Windle, BE; Palit Deb, S; Deb, S; Nieva, JJ; Radhakrishnan, SK ...
Published in: Cancer Res Commun
October 1, 2024
NSCLC is the leading cause of cancer death due, in part, to a lack of active therapies in advanced disease. We demonstrate that combination therapy with a proteasome inhibitor, BH3-mimetic, and chemotherapy is an active precision therapy in NSCLC cells and tumors expressing Onc-p53 alleles.
Duke Scholars
Published In
Cancer Res Commun
DOI
EISSN
2767-9764
Publication Date
October 1, 2024
Volume
4
Issue
10
Start / End Page
2685 / 2698
Location
United States
Related Subject Headings
- Xenograft Model Antitumor Assays
- Tumor Suppressor Protein p53
- Proteasome Inhibitors
- Oxidative Stress
- Mutation
- Mitochondria
- Mice
- Lung Neoplasms
- Humans
- Cell Line, Tumor
Citation
APA
Chicago
ICMJE
MLA
NLM
Chougoni, K. K., Neely, V., Ding, B., Oduah, E., Lam, V. T., Hu, B., … Grossman, S. R. (2024). Oncogenic Mutant p53 Sensitizes Non-Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress-Dependent Induction of Mitochondrial Apoptosis. Cancer Res Commun, 4(10), 2685–2698. https://doi.org/10.1158/2767-9764.CRC-23-0637
Chougoni, Kranthi Kumar, Victoria Neely, Boxiao Ding, Eziafa Oduah, Vianna T. Lam, Bin Hu, Jennifer E. Koblinski, et al. “Oncogenic Mutant p53 Sensitizes Non-Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress-Dependent Induction of Mitochondrial Apoptosis.” Cancer Res Commun 4, no. 10 (October 1, 2024): 2685–98. https://doi.org/10.1158/2767-9764.CRC-23-0637.
Chougoni KK, Neely V, Ding B, Oduah E, Lam VT, Hu B, et al. Oncogenic Mutant p53 Sensitizes Non-Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress-Dependent Induction of Mitochondrial Apoptosis. Cancer Res Commun. 2024 Oct 1;4(10):2685–98.
Chougoni, Kranthi Kumar, et al. “Oncogenic Mutant p53 Sensitizes Non-Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress-Dependent Induction of Mitochondrial Apoptosis.” Cancer Res Commun, vol. 4, no. 10, Oct. 2024, pp. 2685–98. Pubmed, doi:10.1158/2767-9764.CRC-23-0637.
Chougoni KK, Neely V, Ding B, Oduah E, Lam VT, Hu B, Koblinski JE, Windle BE, Palit Deb S, Deb S, Nieva JJ, Radhakrishnan SK, Harada H, Grossman SR. Oncogenic Mutant p53 Sensitizes Non-Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress-Dependent Induction of Mitochondrial Apoptosis. Cancer Res Commun. 2024 Oct 1;4(10):2685–2698.
Published In
Cancer Res Commun
DOI
EISSN
2767-9764
Publication Date
October 1, 2024
Volume
4
Issue
10
Start / End Page
2685 / 2698
Location
United States
Related Subject Headings
- Xenograft Model Antitumor Assays
- Tumor Suppressor Protein p53
- Proteasome Inhibitors
- Oxidative Stress
- Mutation
- Mitochondria
- Mice
- Lung Neoplasms
- Humans
- Cell Line, Tumor