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Overcoming the barriers to better evidence generation from clinical trials.

Publication ,  Journal Article
Kehoe, L; Locke, T; McClellan, M; Landray, M; Hernandez, A; Okun, S
Published in: Trials
September 16, 2024

Clinical evidence generation from and for representative populations can be improved through increased research access and ease of trial participation. To improve access and participation, a modern trial infrastructure is needed that broadens research into more routine practice. This commentary highlights current barriers, areas of advancement, and actions needed to enable continued transformation toward a modern trial infrastructure for an improved evidence generation system. The focus of this commentary is on the development of medical products (e.g., drugs, devices, biologics) and infrastructure issues within the United States, with the aim to have broader, multi-national applicability.

Duke Scholars

Published In

Trials

DOI

EISSN

1745-6215

Publication Date

September 16, 2024

Volume

25

Issue

1

Start / End Page

614

Location

England

Related Subject Headings

  • United States
  • Research Design
  • Patient Selection
  • Humans
  • General & Internal Medicine
  • Evidence-Based Medicine
  • Clinical Trials as Topic
  • Cardiovascular System & Hematology
  • 4203 Health services and systems
  • 4202 Epidemiology
 

Citation

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Kehoe, L., Locke, T., McClellan, M., Landray, M., Hernandez, A., & Okun, S. (2024). Overcoming the barriers to better evidence generation from clinical trials. Trials, 25(1), 614. https://doi.org/10.1186/s13063-024-08460-8
Kehoe, Lindsay, Trevan Locke, Mark McClellan, Martin Landray, Adrian Hernandez, and Sally Okun. “Overcoming the barriers to better evidence generation from clinical trials.Trials 25, no. 1 (September 16, 2024): 614. https://doi.org/10.1186/s13063-024-08460-8.
Kehoe L, Locke T, McClellan M, Landray M, Hernandez A, Okun S. Overcoming the barriers to better evidence generation from clinical trials. Trials. 2024 Sep 16;25(1):614.
Kehoe, Lindsay, et al. “Overcoming the barriers to better evidence generation from clinical trials.Trials, vol. 25, no. 1, Sept. 2024, p. 614. Pubmed, doi:10.1186/s13063-024-08460-8.
Kehoe L, Locke T, McClellan M, Landray M, Hernandez A, Okun S. Overcoming the barriers to better evidence generation from clinical trials. Trials. 2024 Sep 16;25(1):614.
Journal cover image

Published In

Trials

DOI

EISSN

1745-6215

Publication Date

September 16, 2024

Volume

25

Issue

1

Start / End Page

614

Location

England

Related Subject Headings

  • United States
  • Research Design
  • Patient Selection
  • Humans
  • General & Internal Medicine
  • Evidence-Based Medicine
  • Clinical Trials as Topic
  • Cardiovascular System & Hematology
  • 4203 Health services and systems
  • 4202 Epidemiology