Knotting of replication intermediates is narrowly restricted
Publication
, Conference
Buck, D; O’donnol, D
Published in: Contemporary Mathematics
January 1, 2020
The fundamental biological process of DNA replication contains several potential topological pitfalls. These, if not properly managed, lead to cell death. The enzymes (topoisomerases) responsible for averting these topological death warrants can inadvertently knot the same DNA they are supposed to be simplifying. These knotted DNA replication intermediates are still poorly understood. Here, we characterize which knotted forms these DNA molecules can take. Surprisingly, these forms are very narrowly restricted, representing a small fraction of possible entangled configurations.
Duke Scholars
Published In
Contemporary Mathematics
DOI
EISSN
1098-3627
ISSN
0271-4132
Publication Date
January 1, 2020
Volume
746
Start / End Page
85 / 100
Related Subject Headings
- 4904 Pure mathematics
Citation
APA
Chicago
ICMJE
MLA
NLM
Buck, D., & O’donnol, D. (2020). Knotting of replication intermediates is narrowly restricted. In Contemporary Mathematics (Vol. 746, pp. 85–100). https://doi.org/10.1090/conm/746/15003
Buck, D., and D. O’donnol. “Knotting of replication intermediates is narrowly restricted.” In Contemporary Mathematics, 746:85–100, 2020. https://doi.org/10.1090/conm/746/15003.
Buck D, O’donnol D. Knotting of replication intermediates is narrowly restricted. In: Contemporary Mathematics. 2020. p. 85–100.
Buck, D., and D. O’donnol. “Knotting of replication intermediates is narrowly restricted.” Contemporary Mathematics, vol. 746, 2020, pp. 85–100. Scopus, doi:10.1090/conm/746/15003.
Buck D, O’donnol D. Knotting of replication intermediates is narrowly restricted. Contemporary Mathematics. 2020. p. 85–100.
Published In
Contemporary Mathematics
DOI
EISSN
1098-3627
ISSN
0271-4132
Publication Date
January 1, 2020
Volume
746
Start / End Page
85 / 100
Related Subject Headings
- 4904 Pure mathematics