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Behavioral state and stimulus strength regulate the role of somatostatin interneurons in stabilizing network activity.

Publication ,  Journal Article
Cammarata, CM; Pei, Y; Shields, BC; Lim, SSX; Hawley, T; Li, JY; St Amand, D; Brunel, N; Tadross, MR; Glickfeld, LL
Published in: bioRxiv
September 10, 2024

Inhibition stabilization enables cortical circuits to encode sensory signals across diverse contexts. Somatostatin-expressing (SST) interneurons are well-suited for this role through their strong recurrent connectivity with excitatory pyramidal cells. We developed a cortical circuit model predicting that SST cells become increasingly important for stabilization as sensory input strengthens. We tested this prediction in mouse primary visual cortex by manipulating excitatory input to SST cells, a key parameter for inhibition stabilization, with a novel cell-type specific pharmacological method to selectively block glutamatergic receptors on SST cells. Consistent with our model predictions, we find antagonizing glutamatergic receptors drives a paradoxical facilitation of SST cells with increasing stimulus contrast. In addition, we find even stronger engagement of SST-dependent stabilization when the mice are aroused. Thus, we reveal that the role of SST cells in cortical processing gradually switches as a function of both input strength and behavioral state.

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Published In

bioRxiv

DOI

EISSN

2692-8205

Publication Date

September 10, 2024

Location

United States
 

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Cammarata, C. M., Pei, Y., Shields, B. C., Lim, S. S. X., Hawley, T., Li, J. Y., … Glickfeld, L. L. (2024). Behavioral state and stimulus strength regulate the role of somatostatin interneurons in stabilizing network activity. BioRxiv. https://doi.org/10.1101/2024.09.09.612138
Cammarata, Celine M., Yingming Pei, Brenda C. Shields, Shaun S. X. Lim, Tammy Hawley, Jennifer Y. Li, David St Amand, Nicolas Brunel, Michael R. Tadross, and Lindsey L. Glickfeld. “Behavioral state and stimulus strength regulate the role of somatostatin interneurons in stabilizing network activity.BioRxiv, September 10, 2024. https://doi.org/10.1101/2024.09.09.612138.
Cammarata CM, Pei Y, Shields BC, Lim SSX, Hawley T, Li JY, et al. Behavioral state and stimulus strength regulate the role of somatostatin interneurons in stabilizing network activity. bioRxiv. 2024 Sep 10;
Cammarata, Celine M., et al. “Behavioral state and stimulus strength regulate the role of somatostatin interneurons in stabilizing network activity.BioRxiv, Sept. 2024. Pubmed, doi:10.1101/2024.09.09.612138.
Cammarata CM, Pei Y, Shields BC, Lim SSX, Hawley T, Li JY, St Amand D, Brunel N, Tadross MR, Glickfeld LL. Behavioral state and stimulus strength regulate the role of somatostatin interneurons in stabilizing network activity. bioRxiv. 2024 Sep 10;

Published In

bioRxiv

DOI

EISSN

2692-8205

Publication Date

September 10, 2024

Location

United States