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Fast magnetic resonance fingerprinting for dynamic contrast-enhanced studies in mice.

Publication ,  Journal Article
Gu, Y; Wang, CY; Anderson, CE; Liu, Y; Hu, H; Johansen, ML; Ma, D; Jiang, Y; Ramos-Estebanez, C; Brady-Kalnay, S; Griswold, MA; Flask, CA; Yu, X
Published in: Magn Reson Med
December 2018

PURPOSE: The goal of this study was to develop a fast MR fingerprinting (MRF) method for simultaneous T1 and T2 mapping in DCE-MRI studies in mice. METHODS: The MRF sequences based on balanced SSFP and fast imaging with steady-state precession were implemented and evaluated on a 7T preclinical scanner. The readout used a zeroth-moment-compensated variable-density spiral trajectory that fully sampled the entire k-space and the inner 10 × 10 k-space with 48 and 4 interleaves, respectively. In vitro and in vivo studies of mouse brain were performed to evaluate the accuracy of MRF measurements with both fully sampled and undersampled data. The application of MRF to dynamic T1 and T2 mapping in DCE-MRI studies were demonstrated in a mouse model of heterotopic glioblastoma using gadolinium-based and dysprosium-based contrast agents. RESULTS: The T1 and T2 measurements in phantom showed strong agreement between the MRF and the conventional methods. The MRF with spiral encoding allowed up to 8-fold undersampling without loss of measurement accuracy. This enabled simultaneous T1 and T2 mapping with 2-minute temporal resolution in DCE-MRI studies. CONCLUSION: Magnetic resonance fingerprinting provides the opportunity for dynamic quantification of contrast agent distribution in preclinical tumor models on high-field MRI scanners.

Duke Scholars

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Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

December 2018

Volume

80

Issue

6

Start / End Page

2681 / 2690

Location

United States

Related Subject Headings

  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Transplantation
  • Mice, Nude
  • Mice
  • Magnetic Resonance Imaging
  • Linear Models
  • Imaging, Three-Dimensional
  • Image Processing, Computer-Assisted
  • Image Interpretation, Computer-Assisted
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gu, Y., Wang, C. Y., Anderson, C. E., Liu, Y., Hu, H., Johansen, M. L., … Yu, X. (2018). Fast magnetic resonance fingerprinting for dynamic contrast-enhanced studies in mice. Magn Reson Med, 80(6), 2681–2690. https://doi.org/10.1002/mrm.27345
Gu, Yuning, Charlie Y. Wang, Christian E. Anderson, Yuchi Liu, He Hu, Mette L. Johansen, Dan Ma, et al. “Fast magnetic resonance fingerprinting for dynamic contrast-enhanced studies in mice.Magn Reson Med 80, no. 6 (December 2018): 2681–90. https://doi.org/10.1002/mrm.27345.
Gu Y, Wang CY, Anderson CE, Liu Y, Hu H, Johansen ML, et al. Fast magnetic resonance fingerprinting for dynamic contrast-enhanced studies in mice. Magn Reson Med. 2018 Dec;80(6):2681–90.
Gu, Yuning, et al. “Fast magnetic resonance fingerprinting for dynamic contrast-enhanced studies in mice.Magn Reson Med, vol. 80, no. 6, Dec. 2018, pp. 2681–90. Pubmed, doi:10.1002/mrm.27345.
Gu Y, Wang CY, Anderson CE, Liu Y, Hu H, Johansen ML, Ma D, Jiang Y, Ramos-Estebanez C, Brady-Kalnay S, Griswold MA, Flask CA, Yu X. Fast magnetic resonance fingerprinting for dynamic contrast-enhanced studies in mice. Magn Reson Med. 2018 Dec;80(6):2681–2690.
Journal cover image

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

December 2018

Volume

80

Issue

6

Start / End Page

2681 / 2690

Location

United States

Related Subject Headings

  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Transplantation
  • Mice, Nude
  • Mice
  • Magnetic Resonance Imaging
  • Linear Models
  • Imaging, Three-Dimensional
  • Image Processing, Computer-Assisted
  • Image Interpretation, Computer-Assisted