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Long-term Results of Valve-Sparing Aortic Root Replacement in Acute Type A Aortic Dissection.

Publication ,  Journal Article
Leshnower, BG; Farrington, WJ; Huckaby, LV; Keeling, WB; Zellner, AB; Chen, EP
Published in: Ann Thorac Surg
January 2025

BACKGROUND: Valve preservation in acute type A aortic dissection (ATAAD) can be accomplished with root repair or replacement. Long-term valve durability with root repair has been established, but limited data exist regarding long-term durability of valve-sparing root replacement (VSRR). In this study, long-term results of VSRR were compared with root repair in ATAAD. METHODS: From 2005 to 2023, 866 patients underwent ATAAD repair, of which 675 underwent root repair and 191 underwent root replacement (VSRR, n = 65; Bentall, n =126). VSRR patients were compared with 123 patients who underwent valve resuspension and root repair with postoperative echocardiograms ≥1 year. RESULTS: VSRR patients were younger (VSRR, 44 ± 11 years vs root repair, 55 ± 13 years; P < .001). Preoperatively, 57% of VSRR and 35% of root repair patients had moderate or more aortic insufficiency. Cardiopulmonary bypass and myocardial ischemia times were significantly longer in VSRR (P < .001). Postoperative echocardiograms with ≥1 year follow-up were analyzed in 58 VSRR patients with median follow-up of 4.8 years (interquartile range, 3-12 years) and in 123 root repair patients with median follow-up of 3.6 years (interquartile range, 3-8 years). At 10 years, VSRR patients had superior freedom from more than mild aortic insufficiency (VSRR, 91% vs root repair, 49%; P < .001). At 10 years, freedom from aortic valve replacement was equivalent (VSRR, 98% vs root repair, 92%; P = .269). CONCLUSIONS: VSRR provides equivalent long-term valve durability as root repair in ATAAD, even in patients with moderate or severe aortic insufficiency. In select young patients who require root replacement during ATAAD repair, VSRR represents an ideal therapy.

Published In

Ann Thorac Surg

DOI

EISSN

1552-6259

Publication Date

January 2025

Volume

119

Issue

1

Start / End Page

101 / 107

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Retrospective Studies
  • Respiratory System
  • Organ Sparing Treatments
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Leshnower, B. G., Farrington, W. J., Huckaby, L. V., Keeling, W. B., Zellner, A. B., & Chen, E. P. (2025). Long-term Results of Valve-Sparing Aortic Root Replacement in Acute Type A Aortic Dissection. Ann Thorac Surg, 119(1), 101–107. https://doi.org/10.1016/j.athoracsur.2024.09.007
Leshnower, Bradley G., Woodrow J. Farrington, Lauren V. Huckaby, William B. Keeling, Alysa B. Zellner, and Edward P. Chen. “Long-term Results of Valve-Sparing Aortic Root Replacement in Acute Type A Aortic Dissection.Ann Thorac Surg 119, no. 1 (January 2025): 101–7. https://doi.org/10.1016/j.athoracsur.2024.09.007.
Leshnower BG, Farrington WJ, Huckaby LV, Keeling WB, Zellner AB, Chen EP. Long-term Results of Valve-Sparing Aortic Root Replacement in Acute Type A Aortic Dissection. Ann Thorac Surg. 2025 Jan;119(1):101–7.
Leshnower, Bradley G., et al. “Long-term Results of Valve-Sparing Aortic Root Replacement in Acute Type A Aortic Dissection.Ann Thorac Surg, vol. 119, no. 1, Jan. 2025, pp. 101–07. Pubmed, doi:10.1016/j.athoracsur.2024.09.007.
Leshnower BG, Farrington WJ, Huckaby LV, Keeling WB, Zellner AB, Chen EP. Long-term Results of Valve-Sparing Aortic Root Replacement in Acute Type A Aortic Dissection. Ann Thorac Surg. 2025 Jan;119(1):101–107.
Journal cover image

Published In

Ann Thorac Surg

DOI

EISSN

1552-6259

Publication Date

January 2025

Volume

119

Issue

1

Start / End Page

101 / 107

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Retrospective Studies
  • Respiratory System
  • Organ Sparing Treatments
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Female