IL-1 signaling in aging and cancer: An inflammaging feedback loop unveiled.
Publication
, Journal Article
Liu, M; Zhu, B; Li, Q-J
Published in: Cancer Cell
November 11, 2024
In a Science paper, Park et al. identified interleukin (IL)-1α as a key driver of positive feedback in inflammaging, linking aging-associated downregulation of DNMT3A to increased IL-1α production in lung myeloid cells. This triggers emergency myelopoiesis in the bone marrow, amplifying myeloid-mediated intratumoral immunosuppression for tumor progression in aged mice.
Duke Scholars
Published In
Cancer Cell
DOI
EISSN
1878-3686
Publication Date
November 11, 2024
Volume
42
Issue
11
Start / End Page
1820 / 1822
Location
United States
Related Subject Headings
- Signal Transduction
- Oncology & Carcinogenesis
- Neoplasms
- Myeloid Cells
- Mice
- Interleukin-1alpha
- Interleukin-1
- Inflammation
- Humans
- Feedback, Physiological
Citation
APA
Chicago
ICMJE
MLA
NLM
Liu, M., Zhu, B., & Li, Q.-J. (2024). IL-1 signaling in aging and cancer: An inflammaging feedback loop unveiled. Cancer Cell, 42(11), 1820–1822. https://doi.org/10.1016/j.ccell.2024.09.015
Liu, Mingyong, Bo Zhu, and Qi-Jing Li. “IL-1 signaling in aging and cancer: An inflammaging feedback loop unveiled.” Cancer Cell 42, no. 11 (November 11, 2024): 1820–22. https://doi.org/10.1016/j.ccell.2024.09.015.
Liu M, Zhu B, Li Q-J. IL-1 signaling in aging and cancer: An inflammaging feedback loop unveiled. Cancer Cell. 2024 Nov 11;42(11):1820–2.
Liu, Mingyong, et al. “IL-1 signaling in aging and cancer: An inflammaging feedback loop unveiled.” Cancer Cell, vol. 42, no. 11, Nov. 2024, pp. 1820–22. Pubmed, doi:10.1016/j.ccell.2024.09.015.
Liu M, Zhu B, Li Q-J. IL-1 signaling in aging and cancer: An inflammaging feedback loop unveiled. Cancer Cell. 2024 Nov 11;42(11):1820–1822.
Published In
Cancer Cell
DOI
EISSN
1878-3686
Publication Date
November 11, 2024
Volume
42
Issue
11
Start / End Page
1820 / 1822
Location
United States
Related Subject Headings
- Signal Transduction
- Oncology & Carcinogenesis
- Neoplasms
- Myeloid Cells
- Mice
- Interleukin-1alpha
- Interleukin-1
- Inflammation
- Humans
- Feedback, Physiological