Skip to main content

Ex vivo expansion and hydrogel-mediated in vivo delivery of tissue-resident memory T cells for immunotherapy.

Publication ,  Journal Article
Li, S; Yao, Z-C; Wang, H; Ecker, JA; Omotoso, MO; Lee, J; Kong, J; Feng, H; Chaisawangwong, W; Kang, S-S; Shannon, SR; Livingston, NK ...
Published in: Science advances
December 2024

Tissue-resident memory T (TRM) cells preferentially reside in peripheral tissues, serving as key players in tumor immunity and immunotherapy. The lack of effective approaches for expanding TRM cells and delivering these cells in vivo hinders the exploration of TRM cell-mediated cancer immunotherapy. Here, we report a nanoparticle artificial antigen-presenting cell (nano-aAPC) ex vivo expansion approach and an in vivo delivery system for TRM cells. Using the nano-aAPC platform, we expanded functional antigen-specific murine and human TRM-like CD8+ T cells ex vivo. We also developed an injectable macroporous hyaluronic acid (HA) hydrogel to deliver TRM-like cells. TRM-like cells delivered in the optimized HA hydrogel trigger robust local and systemic antitumor immunity and show synergistic effects with anti-PD-1 treatment. Our findings suggest that nano-aAPC-induced TRM-like cells, coupled with a hydrogel delivery system, offer an efficient way to advance the understanding of TRM cell-mediated cancer therapy.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Science advances

DOI

EISSN

2375-2548

ISSN

2375-2548

Publication Date

December 2024

Volume

10

Issue

50

Start / End Page

eadm7928

Related Subject Headings

  • Neoplasms
  • Nanoparticles
  • Mice
  • Memory T Cells
  • Immunotherapy
  • Immunologic Memory
  • Hydrogels
  • Hyaluronic Acid
  • Humans
  • CD8-Positive T-Lymphocytes
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, S., Yao, Z.-C., Wang, H., Ecker, J. A., Omotoso, M. O., Lee, J., … Schneck, J. P. (2024). Ex vivo expansion and hydrogel-mediated in vivo delivery of tissue-resident memory T cells for immunotherapy. Science Advances, 10(50), eadm7928. https://doi.org/10.1126/sciadv.adm7928
Li, Shuyi, Zhi-Cheng Yao, Hanzhi Wang, Jonathan A. Ecker, Mary O. Omotoso, Jaechan Lee, Jiayuan Kong, et al. “Ex vivo expansion and hydrogel-mediated in vivo delivery of tissue-resident memory T cells for immunotherapy.Science Advances 10, no. 50 (December 2024): eadm7928. https://doi.org/10.1126/sciadv.adm7928.
Li S, Yao Z-C, Wang H, Ecker JA, Omotoso MO, Lee J, et al. Ex vivo expansion and hydrogel-mediated in vivo delivery of tissue-resident memory T cells for immunotherapy. Science advances. 2024 Dec;10(50):eadm7928.
Li, Shuyi, et al. “Ex vivo expansion and hydrogel-mediated in vivo delivery of tissue-resident memory T cells for immunotherapy.Science Advances, vol. 10, no. 50, Dec. 2024, p. eadm7928. Epmc, doi:10.1126/sciadv.adm7928.
Li S, Yao Z-C, Wang H, Ecker JA, Omotoso MO, Lee J, Kong J, Feng H, Chaisawangwong W, Kang S-S, Shannon SR, Livingston NK, Bieler JG, Singh S, Zhang ML, O’Neal P, Ariail E, Biggs B, Hickey JW, Mao H-Q, Schneck JP. Ex vivo expansion and hydrogel-mediated in vivo delivery of tissue-resident memory T cells for immunotherapy. Science advances. 2024 Dec;10(50):eadm7928.

Published In

Science advances

DOI

EISSN

2375-2548

ISSN

2375-2548

Publication Date

December 2024

Volume

10

Issue

50

Start / End Page

eadm7928

Related Subject Headings

  • Neoplasms
  • Nanoparticles
  • Mice
  • Memory T Cells
  • Immunotherapy
  • Immunologic Memory
  • Hydrogels
  • Hyaluronic Acid
  • Humans
  • CD8-Positive T-Lymphocytes