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Efficacy of a couple-based intervention addressing sexual concerns for breast cancer survivors: Results of a randomized controlled trial.

Publication ,  Journal Article
Reese, JB; Lepore, SJ; Sorice, KA; Zimmaro, LA; Hasler, J; Handorf, E; Daly, MB; Zaleta, AK; Westbrook, K; Porter, LS
Published in: Cancer
January 1, 2025

BACKGROUND: Sexual concerns are common and problematic for breast cancer survivors. Partner and relationship factors often play a key role in determining survivors' sexual adjustment, making it likely that couple-based interventions that integrate survivors' partners could be especially promising for addressing survivors' sexual concerns. Yet few such interventions have been tested. The objective of this study was to evaluate the efficacy of the Intimacy Enhancement (IE) intervention, a four-session, couple-based intervention addressing breast cancer survivors' sexual concerns by telephone in a randomized controlled trial. METHODS: Female posttreatment breast cancer survivors reporting sexual concerns and their intimate partners (N = 120 couples; 240 participants) were randomized either to the IE intervention or to Living Healthy Together (LHT), an active control intervention of equivalent length. Outcomes (measured at baseline, postintervention, and at 3 and 6 months postintervention) included breast cancer survivors' sexual function (primary), partners' sexual function (secondary), and survivors' and partners' psychosocial and relationship outcomes (secondary). Mixed linear regression models examined intervention effects on outcomes at all follow-ups. RESULTS: Model-based estimates of intervention effects showed greater improvements in survivors' overall sexual function, sexual satisfaction, arousal, lubrication, and orgasm at postintervention (p < .05). Effects on survivors' 3-month and 6-month sexual functioning or other secondary outcomes were minimal. Most couples completed all IE sessions (97%) and LHT (92%), and satisfaction ratings were high. CONCLUSIONS: Compared with an active control intervention, the IE intervention had significant short-term benefits for survivors' sexual function. Efforts may be needed to increase the longevity of the positive effects, such as more frequent or adjunctive treatments.

Duke Scholars

Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

January 1, 2025

Volume

131

Issue

1

Start / End Page

e35685

Location

United States

Related Subject Headings

  • Sexual Partners
  • Sexual Dysfunction, Physiological
  • Sexual Behavior
  • Quality of Life
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Female
  • Cancer Survivors
 

Citation

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Chicago
ICMJE
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Reese, J. B., Lepore, S. J., Sorice, K. A., Zimmaro, L. A., Hasler, J., Handorf, E., … Porter, L. S. (2025). Efficacy of a couple-based intervention addressing sexual concerns for breast cancer survivors: Results of a randomized controlled trial. Cancer, 131(1), e35685. https://doi.org/10.1002/cncr.35685
Reese, Jennifer Barsky, Stephen J. Lepore, Kristen A. Sorice, Lauren A. Zimmaro, Jill Hasler, Elizabeth Handorf, Mary B. Daly, Alexandra K. Zaleta, Kelly Westbrook, and Laura S. Porter. “Efficacy of a couple-based intervention addressing sexual concerns for breast cancer survivors: Results of a randomized controlled trial.Cancer 131, no. 1 (January 1, 2025): e35685. https://doi.org/10.1002/cncr.35685.
Reese JB, Lepore SJ, Sorice KA, Zimmaro LA, Hasler J, Handorf E, et al. Efficacy of a couple-based intervention addressing sexual concerns for breast cancer survivors: Results of a randomized controlled trial. Cancer. 2025 Jan 1;131(1):e35685.
Reese, Jennifer Barsky, et al. “Efficacy of a couple-based intervention addressing sexual concerns for breast cancer survivors: Results of a randomized controlled trial.Cancer, vol. 131, no. 1, Jan. 2025, p. e35685. Pubmed, doi:10.1002/cncr.35685.
Reese JB, Lepore SJ, Sorice KA, Zimmaro LA, Hasler J, Handorf E, Daly MB, Zaleta AK, Westbrook K, Porter LS. Efficacy of a couple-based intervention addressing sexual concerns for breast cancer survivors: Results of a randomized controlled trial. Cancer. 2025 Jan 1;131(1):e35685.
Journal cover image

Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

January 1, 2025

Volume

131

Issue

1

Start / End Page

e35685

Location

United States

Related Subject Headings

  • Sexual Partners
  • Sexual Dysfunction, Physiological
  • Sexual Behavior
  • Quality of Life
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Female
  • Cancer Survivors