Scholars@Duke publication: An extensive exploration of the rat brain for sites mediating prostaglandin-induced hyperthermia.

An extensive exploration of the rat brain for sites mediating prostaglandin-induced hyperthermia.

Publication , Journal Article

Williams, JW; Rudy, TA; Yaksh, TL; Viswanathan, CT

Published in: Brain Res

January 21, 1977

Experiments designed to ascertain the site or sites within the brain where prostaglandins act to evoke hyperthermia were carried out. At an ambient temperature of 20 degrees C, microinjections of PGE1 (50-100 ng) or saline vehicle were made in restrained rats. The 272 sites tested formed a matrix encompassing much of the subcortical tissue rostral to the medulla. The sensitivity of each site to PGE1 was evaluated on the basis of the dose required to elicit a criterion level of effect and on the intensity of the effect evoked by a fixed dose. Injections of PGE1 into a sensitive site typically produced a rapidly developing, short lasting, monophasic rise in body temperature. Saline injected at these sites produced no initial hyperthermia. Almost all of the active sites were located within the anterior hypothalamic/preoptic region (AH/PO). The sites of greatest reactivity were found in the ventral aspect of the tissue lying between the anterior commissure and the optic chiasm. These data suggest that the AH/PO region is an important and probably the only supramedullary site of PGE1 action in the rat brain.

Duke Scholars

Author John Wiley Williams Jr. Medicine, General Internal Medicine

Published In

Brain Res

DOI

10.1016/0006-8993(77)90904-0

ISSN

0006-8993

Publication Date

January 21, 1977

Volume

120

Issue

Start / End Page

251 / 262

Location

Netherlands

Related Subject Headings

Rats
Prostaglandins E
Preoptic Area
Neurology & Neurosurgery
Male
Injections
Hypothalamus, Anterior
Hypothalamus
Colon
Brain Mapping

Citation

APA

Chicago

ICMJE

MLA

NLM

Williams, J. W., Rudy, T. A., Yaksh, T. L., & Viswanathan, C. T. (1977). An extensive exploration of the rat brain for sites mediating prostaglandin-induced hyperthermia. Brain Res, 120(2), 251–262. https://doi.org/10.1016/0006-8993(77)90904-0

Williams, J. W., T. A. Rudy, T. L. Yaksh, and C. T. Viswanathan. “An extensive exploration of the rat brain for sites mediating prostaglandin-induced hyperthermia.” Brain Res 120, no. 2 (January 21, 1977): 251–62. https://doi.org/10.1016/0006-8993(77)90904-0.

Williams JW, Rudy TA, Yaksh TL, Viswanathan CT. An extensive exploration of the rat brain for sites mediating prostaglandin-induced hyperthermia. Brain Res. 1977 Jan 21;120(2):251–62.

Williams, J. W., et al. “An extensive exploration of the rat brain for sites mediating prostaglandin-induced hyperthermia.” Brain Res, vol. 120, no. 2, Jan. 1977, pp. 251–62. Pubmed, doi:10.1016/0006-8993(77)90904-0.

Williams JW, Rudy TA, Yaksh TL, Viswanathan CT. An extensive exploration of the rat brain for sites mediating prostaglandin-induced hyperthermia. Brain Res. 1977 Jan 21;120(2):251–262.